Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL9044839 | 0.82 | HTR1A (0.38) | RORCLMNAKMT2ACYP2C9CYP3A4 | |
| Bicarbonate SCHEMBL9046002 | 0.80 | MAPK8 (0.47) | RORCKDM4EMAPTCYP2C9SMN1; SMN2 | |
| SCHEMBL9055849 | 0.75 | MAOA (0.45) | LMNAMAPT | |
| SCHEMBL9044266 | 0.72 | TDP1 (0.44) | RORCKDM4ELMNAKMT2AALDH1A1 | |
| SCHEMBL1883370 | 0.71 | KDM4E (0.45) | RORCKDM4ELMNAKCNH2KMT2A | |
| SCHEMBL31533281 | 0.70 | ATM (0.40) | LMNAALDH1A1MAPT | |
| SCHEMBL10627492 | 0.70 | ATM (0.47) | KDM4EALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL14984898 | 0.70 | ALDH1A1 (0.41) | RORCKDM4ELMNAKCNH2ALDH1A1 | |
| SCHEMBL1876893 | 0.70 | LMNA (0.43) | KDM4ELMNAKMT2AALDH1A1HPGD | |
| SCHEMBL10475470 | 0.70 | KCNH2 (0.58) | RORCKDM4ELMNAKCNH2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0422485-B1 | Quinolone carboxylic acid derivatives, process for their preparation and their use | BAYER AG (DE) | 1996-04-03 | — | — | EP | disclosed |
| EP-0422485-A2 | Quinolone carboxylic acid derivatives, process for their preparation and their use | BAYER AG (DE) | 1991-04-17 | — | — | EP | disclosed |