Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045141 | 0.89 | CRHR1 (0.39) | DYRK1ACRHR1KDM4EALDH1A1LMNA | |
| SCHEMBL9046169 | 0.85 | CRHR1 (0.39) | DYRK1ACRHR1KDM4E | |
| SCHEMBL9046257 | 0.78 | KDM4E (0.42) | DYRK1ACRHR1KDM4EALDH1A1 | |
| SCHEMBL9045363 | 0.77 | CRHR1 (0.37) | CRHR1KDM4ELMNA | |
| SCHEMBL9047904 | 0.76 | CRHR1 (0.33) | CRHR1KDM4EALDH1A1LMNA | |
| SCHEMBL9057759 | 0.73 | LMNA (0.39) | DYRK1ACRHR1KDM4EALDH1A1LMNA | |
| SCHEMBL7676370 | 0.66 | CRHR1 (0.39) | CRHR1 | |
| SCHEMBL9046491 | 0.61 | CRHR1 (0.41) | CRHR1KDM4EALDH1A1LMNA | |
| SCHEMBL5107762 | 0.61 | CRHR1 (0.37) | CRHR1 | |
| SCHEMBL9045862 | 0.61 | KDM4E (0.47) | CRHR1KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | claimed |
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | disclosed |