Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 4/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046169 | 0.87 | CRHR1 (0.39) | KDM4EHSD17B10CRHR1DYRK1A | |
| SCHEMBL9045141 | 0.86 | CRHR1 (0.39) | KDM4EALDH1A1CRHR1DYRK1A | |
| SCHEMBL9045363 | 0.79 | CRHR1 (0.37) | KDM4ECRHR1 | |
| SCHEMBL9045192 | 0.78 | DYRK1A (0.34) | KDM4EALDH1A1CRHR1DYRK1A | |
| SCHEMBL9046572 | 0.75 | CRHR1 (0.43) | CRHR1 | |
| SCHEMBL9047904 | 0.72 | CRHR1 (0.33) | KDM4EALDH1A1CRHR1L3MBTL1 | |
| SCHEMBL7678511 | 0.69 | CRHR1 (0.41) | KDM4EHPGDALDH1A1HSD17B10CRHR1 | |
| SCHEMBL9045862 | 0.63 | KDM4E (0.47) | KDM4EALDH1A1CRHR1 | |
| SCHEMBL7678441 | 0.63 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL9047218 | 0.63 | CRHR1 (0.43) | KDM4EALDH1A1CRHR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | claimed |
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | disclosed |