Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9046169 | 0.89 | CRHR1 (0.39) | CRHR1DYRK1AGPR119KDM4E | |
| SCHEMBL9045192 | 0.89 | DYRK1A (0.34) | CRHR1LMNADYRK1AALDH1A1KDM4E | |
| SCHEMBL9046257 | 0.86 | KDM4E (0.42) | CRHR1DYRK1AALDH1A1KDM4E | |
| SCHEMBL9045363 | 0.83 | CRHR1 (0.37) | CRHR1LMNAKDM4E | |
| SCHEMBL9047904 | 0.73 | CRHR1 (0.33) | CRHR1LMNAALDH1A1KDM4E | |
| SCHEMBL9045862 | 0.72 | KDM4E (0.47) | CRHR1LMNAALDH1A1KDM4E | |
| SCHEMBL9049223 | 0.66 | EIF4A3 (0.36) | CRHR1LMNA | |
| SCHEMBL9046491 | 0.65 | CRHR1 (0.41) | CRHR1LMNAALDH1A1KDM4E | |
| SCHEMBL7684958 | 0.64 | CRHR1 (0.40) | CRHR1 | |
| SCHEMBL9046572 | 0.63 | CRHR1 (0.43) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | claimed |
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | disclosed |