Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 9/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 9/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9047416 | 0.91 | ADORA1 (0.38) | CSNK1DCSNK1ELMNAADORA1ABL1 | |
| SCHEMBL9044712 | 0.90 | ADORA1 (0.38) | CSNK1DCSNK1ELMNAADORA1CNR1 | |
| SCHEMBL9046321 | 0.90 | ADORA1 (0.46) | CSNK1DCSNK1EADORA1 | |
| SCHEMBL9046606 | 0.89 | NPC1 (0.42) | CSNK1DCSNK1EADORA1ABL1NPY2R | |
| SCHEMBL9045504 | 0.88 | NR3C2 (0.39) | LMNAADORA1NR3C2 | |
| SCHEMBL9045449 | 0.88 | YTHDC1 (0.39) | LMNAADORA1 | |
| SCHEMBL9043718 | 0.80 | ATIC (0.43) | — | |
| SCHEMBL9045922 | 0.78 | TAS1R3 (0.35) | — | |
| SCHEMBL9471802 | 0.78 | MAPK1 (0.45) | LMNAMGAT2KDM5AKDM5B | |
| SCHEMBL9045967 | 0.76 | SMN1; SMN2 (0.39) | LMNAMGAT2KDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0432677-B1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | UNIV PRINCETON (US) | 1996-03-06 | — | — | EP | disclosed |
| US-5344932-A | N-(pyrrolo(2,3-d)pyrimidin-3-ylacyl)-glutamic acid derivatives | TRUSTEES OF PRINCETON UNIVERSITY (US) | 1994-09-06 | — | — | US | disclosed |
| US-5248775-A | Pyrrolo(2,3-d)pyrimidines | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1993-09-28 | — | — | US | disclosed |
| EP-0432677-A1 | N-(pyrrolo[2,3-d]pyrimidin-3-ylacyl)-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-06-19 | — | — | EP | disclosed |