Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 8/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9045862 | 0.84 | KDM4E (0.47) | CRHR1 | |
| SCHEMBL9047218 | 0.83 | CRHR1 (0.43) | CRHR1ADORA2AADORA1METAP2 | |
| SCHEMBL9046491 | 0.82 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL9049223 | 0.77 | EIF4A3 (0.36) | CRHR1ADORA2AADORA1 | |
| SCHEMBL9057759 | 0.75 | LMNA (0.39) | CRHR1CDK5 | |
| SCHEMBL9046257 | 0.75 | KDM4E (0.42) | CRHR1 | |
| SCHEMBL7678441 | 0.70 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL27852587 | 0.68 | ALDH1A1 (0.48) | CRHR1METAP2 | |
| SCHEMBL10878363 | 0.66 | LMNA (0.54) | METAP2 | |
| SCHEMBL9045363 | 0.66 | CRHR1 (0.37) | CRHR1ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | claimed |
| EP-0723533-A1 | 1N-ALKYL-N-ARYLPYRIMIDINAMINES AND DERIVATIVES THEREOF | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-07-31 | — | — | EP | disclosed |