Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538318 | 0.83 | SIGMAR1 (0.49) | SIGMAR1MEN1KMT2APOLB | |
| SCHEMBL8522922 | 0.77 | SLC6A4 (0.47) | SLC6A4SLC6A2SLC6A3SIGMAR1MEN1 | |
| SCHEMBL6618819 | 0.75 | SLC6A4 (0.63) | SLC6A4SLC6A2SLC6A3SIGMAR1MEN1 | |
| SCHEMBL10913131 | 0.75 | KMT2A (0.50) | SLC6A4SLC6A2SLC6A3SIGMAR1MEN1 | |
| SCHEMBL10316558 | 0.74 | SIGMAR1 (0.50) | SLC6A4SLC6A2SLC6A3SIGMAR1MEN1 | |
| SCHEMBL8636249 | 0.74 | ALDH1A1 (0.45) | MEN1KMT2AACHEPOLB | |
| SCHEMBL3389599 | 0.71 | CHRM5 (0.35) | SLC6A4SLC6A2SIGMAR1MEN1KMT2A | |
| SCHEMBL14141763 | 0.71 | SLC6A4 (0.50) | SLC6A4SLC6A2SLC6A3SIGMAR1MEN1 | |
| Hydrochloric Acid SCHEMBL11384741 | 0.71 | SLC6A4 (0.43) | SLC6A4SLC6A2SLC6A3SIGMAR1MEN1 | |
| SCHEMBL27878470 | 0.71 | ALDH1A1 (0.49) | SLC6A4SLC6A2SLC6A3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0703908-A1 | ANALGESIC DIBENZOXAZEPINES AND DIBENZOTHIAZEPINES | G.D. SEARLE & CO. (US) | 1996-04-03 | — | — | EP | disclosed |
| US-5461047-A | Analgesics and treats prostaglandin-E2 mediated diseases in animals | G. D. SEARLE & CO. (US) | 1995-10-24 | — | — | US | disclosed |
| WO-1994029286-A1 | ANALGESIC DIBENZOXAZEPINES AND DIBENZOTHIAZEPINES | G.D. SEARLE & CO. (US) | 1994-12-22 | — | — | WO | disclosed |
| US-5354747-A | Analgesics | G. D. SEARLE & CO. (US) | 1994-10-11 | — | — | US | disclosed |