Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | HAO1 | Q9UJM8 | 10/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MELK | Q14680 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9049046 | 0.84 | EGFR (0.43) | ALOX5F2F10HAO1EGFR | |
| SCHEMBL9050814 | 0.84 | GRM5 (0.47) | HAO1 | |
| SCHEMBL9050229 | 0.80 | TLR4 (0.42) | ALOX5HAO1MAP4K4ALDH1A1MELK | |
| SCHEMBL9490952 | 0.77 | L3MBTL1 (0.62) | L3MBTL1PPARGF2F10MAP4K4 | |
| SCHEMBL9386945 | 0.76 | ALOX5 (0.59) | ALOX5HAO1ALDH1A1 | |
| SCHEMBL959384 | 0.73 | L3MBTL1 (0.57) | L3MBTL1PPARGF2F10MAP4K4 | |
| SCHEMBL9494460 | 0.72 | L3MBTL1 (0.56) | L3MBTL1PPARGF2F10HAO1 | |
| SCHEMBL2155272 | 0.71 | CHRM2 (0.56) | HAO1EGFR | |
| SCHEMBL9047258 | 0.71 | ALOX5 (0.69) | L3MBTL1ALOX5 | |
| SCHEMBL2144034 | 0.70 | L3MBTL1 (0.54) | L3MBTL1PPARGF2F10HAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0540673-B1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1996-10-16 | — | — | EP | disclosed |
| US-5559144-A | LIPOXYGENASE INHIBITORS, INHIBITORS OF BIOSYNTHESIS OF LEUKOTRIENES | ABBOTT LABORATORIES (US) | 1996-09-24 | — | — | US | disclosed |
| US-5476873-A | Inhibit biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1995-12-19 | — | — | US | disclosed |
| EP-0540673-A4 | — | — | 1994-04-27 | — | — | EP | disclosed |
| EP-0540673-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY. | ABBOTT LAB (US) | 1993-05-12 | — | — | EP | disclosed |
| WO-1992001682-A1 | ACETYLENE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LABORATORIES (US) | 1992-02-06 | — | — | WO | disclosed |