Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 7/20 | 0.60 |
| ▸ | DRD2 | P14416 | 7/20 | 0.60 |
| ▸ | HTR7 | P34969 | 2/20 | 0.60 |
| ▸ | DRD5 | P21918 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 3/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9049703 | 0.94 | DRD3 (0.69) | DRD3DRD2HTR7DRD5HTR1A | |
| SCHEMBL9047811 | 0.94 | DRD3 (0.68) | DRD3DRD2HTR7DRD5HTR1A | |
| SCHEMBL9049487 | 0.89 | DRD3 (0.58) | DRD3DRD2HTR7DRD5HTR1A | |
| SCHEMBL9050903 | 0.89 | DRD3 (0.52) | DRD3DRD2HTR7DRD5HTR1A | |
| SCHEMBL9048438 | 0.88 | ADRA1D (0.52) | DRD3DRD2HTR7DRD5HTR1A | |
| SCHEMBL9049252 | 0.85 | ADRA1B (0.57) | HTR7HTR1AADRA1AADRA1DADRA1B | |
| SCHEMBL9050125 | 0.83 | DRD3 (0.64) | DRD3DRD2HTR7DRD5HTR1A | |
| SCHEMBL9047511 | 0.80 | HTR1A (0.54) | DRD3DRD2HTR7DRD5HTR1A | |
| SCHEMBL28273850 | 0.80 | HTR1A (0.77) | DRD3DRD2HTR7DRD5HTR1A | |
| SCHEMBL7668612 | 0.79 | DRD2 (0.86) | DRD3DRD2HTR7HTR1AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527081-B1 | Substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazine-4-ones, their preparation and their therapeutical use | PF MEDICAMENT (FR) | 1996-01-03 | — | — | EP | claimed |
| US-5308844-A | ANTIDEPRESSANT, ANXIOLYTIC AGENT, ANALGESIC, HYPOTENSIVE AGENT | PIERRE FABRE MEDICAMENT (FR) | 1994-05-03 | — | — | US | disclosed |