SCHEMBL9050273

SCHEMBL9050273

COc1ccc(-n2cc(NCCO)c(C)n2)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.45
RAB9A P51151 4/20 0.44
ALDH1A1 P00352 4/20 0.43
KDM4E B2RXH2 2/20 0.43
TP53 P04637 1/20 0.43
HPGD P15428 1/20 0.43
HSD17B10 Q99714 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.42
HTT P42858 1/20 0.42
GRM1 Q13255 1/20 0.42
ADORA3 P0DMS8 2/20 0.40
CNR1 P21554 3/20 0.40
KMT2A Q03164 3/20 0.40
MEN1 O00255 2/20 0.40
MAPKAPK2 P49137 2/20 0.40
CCNE1 P24864 1/20 0.39
CDK2 P24941 1/20 0.39
CNR2 P34972 2/20 0.39
GPR55 Q9Y2T6 1/20 0.39
GPR35 Q9HC97 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9052034 0.86 TSHR (0.46) RAB9AALDH1A1KDM4ETP53HPGD
SCHEMBL9051881 0.83 LMNA (0.46) RAB9AALDH1A1KDM4EHPGDHSD17B10
SCHEMBL9052432 0.76 GBA1 (0.42) ALDH1A1KDM4EHSD17B10HTTADORA3
SCHEMBL23400552 0.73 RAB9A (0.47) P2RX7RAB9AALDH1A1KDM4ESMN1; SMN2
SCHEMBL1801104 0.71 LMNA (0.48) RAB9AALDH1A1KDM4ETP53HPGD
SCHEMBL717969 0.71 RAB9A (0.61) P2RX7RAB9AALDH1A1KDM4EHSD17B10
SCHEMBL27191952 0.71 ADORA3 (0.47) P2RX7RAB9AALDH1A1KDM4ESMN1; SMN2
SCHEMBL719038 0.70 L3MBTL1 (0.62) ALDH1A1TP53ADORA3KMT2AMEN1
SCHEMBL8073036 0.70 ALDH1A1 (0.57) RAB9AALDH1A1KDM4ETP53HPGD
SCHEMBL20856903 0.69 RAB9A (0.59) P2RX7RAB9AALDH1A1KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1996034591-A1 DIAMINOPYRAZOLE-CONTAINING COMPOSITIONS FOR COLOURING KERATIN FIBRES, COLOURING PROCESS, NOVEL DIAMINOPYRAZOLES AND METHOD FOR THEIR PREPARATION L'OREAL (FR) 1996-11-07 WO claimed