Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | ULK1 | O75385 | 1/20 | 0.48 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9050861 | 0.92 | POLB (0.54) | POLBULK1ABL1HPGDALDH1A1 | |
| SCHEMBL6851321 | 0.78 | HPGD (0.48) | POLBHPGDHSD17B10KDM4EMAPT | |
| SCHEMBL9050448 | 0.76 | TRPV1 (0.47) | POLBALDH1A1HSD17B10TRPV1KDM4E | |
| SCHEMBL9048814 | 0.75 | GSK3A (0.47) | POLBHPGDALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL7333785 | 0.75 | MMP8 (0.47) | POLBHPGDALDH1A1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL9051872 | 0.74 | GSK3A (0.46) | POLBHPGDALDH1A1CYP1A2CYP2C9 | |
| Fumaric Acid SCHEMBL7334141 | 0.73 | HPGD (0.43) | HPGDHSD17B10KDM4EMAPTRAB9A | |
| SCHEMBL9049321 | 0.72 | NPSR1 (0.52) | HPGDALDH1A1KDM4EMAPTRAB9A | |
| SCHEMBL12060045 | 0.72 | POLB (0.90) | POLBULK1ABL1ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL9050917 | 0.71 | HTR3A (0.39) | HPGDALDH1A1CYP2D6P2RX7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381422-B1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1996-10-23 | — | — | EP | disclosed |
| US-5496942-A | 5-HT3-RECEPTOR ANTAGONISTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| US-5344927-A | 5-HT3 antagonist | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1994-09-06 | — | — | US | disclosed |
| EP-0381422-A1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-08-08 | — | — | EP | disclosed |