Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6851321 | 0.83 | HPGD (0.48) | RAB9AMAPTKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL6850904 | 0.82 | KDM2B (0.47) | CNR2 | |
| Fumaric Acid SCHEMBL7334141 | 0.78 | HPGD (0.43) | RAB9AMAPTKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL9048814 | 0.78 | GSK3A (0.47) | RAB9AKDM4ENPC1POLBALDH1A1 | |
| SCHEMBL9049386 | 0.78 | CYP1A2 (0.49) | RAB9AMAPTKDM4ENPC1SMN1; SMN2 | |
| SCHEMBL9050232 | 0.78 | SMN1; SMN2 (0.63) | RAB9AMAPTNPC1SMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL9051872 | 0.78 | GSK3A (0.46) | RAB9AKDM4ENPC1POLBALDH1A1 | |
| SCHEMBL9050851 | 0.76 | POLB (0.54) | TRPV1RAB9AMAPTKDM4ENPC1 | |
| SCHEMBL7327986 | 0.75 | L3MBTL1 (0.47) | RAB9AEPHX2KDM4ENPC1SMN1; SMN2 | |
| SCHEMBL7325548 | 0.75 | SMN1; SMN2 (0.45) | RAB9ANPC1SMN1; SMN2TP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381422-B1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1996-10-23 | — | — | EP | disclosed |
| US-5496942-A | 5-HT3-RECEPTOR ANTAGONISTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| US-5344927-A | 5-HT3 antagonist | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1994-09-06 | — | — | US | disclosed |
| EP-0381422-A1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-08-08 | — | — | EP | disclosed |