Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9050466 | 0.88 | SIRT1 (0.36) | SMN1; SMN2ALOX15KMT2AMAPTALDH1A1 | |
| SCHEMBL9050442 | 0.86 | MTNR1A (0.36) | ALOX15KMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL9052108 | 0.81 | HTR3A (0.46) | RAB9ASMN1; SMN2KMT2AMAPTALDH1A1 | |
| SCHEMBL9052277 | 0.77 | ADRA2A (0.55) | RAB9ASMN1; SMN2ALOX15MAPTALDH1A1 | |
| SCHEMBL9048666 | 0.77 | ADRA2A (0.55) | RAB9ASMN1; SMN2ALOX15MAPTALDH1A1 | |
| SCHEMBL9052002 | 0.76 | ALDH1A1 (0.36) | RAB9ASMN1; SMN2ALOX15MAPTALDH1A1 | |
| SCHEMBL9049337 | 0.74 | HTR3A (0.48) | RAB9ASMN1; SMN2ALOX15KMT2AMAPT | |
| SCHEMBL6271791 | 0.74 | HTR3A (0.48) | RAB9ASMN1; SMN2ALOX15KMT2AMAPT | |
| Fumaric Acid SCHEMBL9050456 | 0.73 | HTR3A (0.43) | RAB9ASMN1; SMN2ALOX15KMT2AMAPT | |
| SCHEMBL9051282 | 0.72 | CNR2 (0.48) | SMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381422-B1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1996-10-23 | — | — | EP | disclosed |
| EP-0381422-A1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1990-08-08 | — | — | EP | disclosed |