SCHEMBL9052145

SCHEMBL9052145

O=[N+]([O-])c1cc(Cl)c(F)cc1C(O)O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR35 Q9HC97 2/20 0.39
SLC6A4 P31645 1/20 0.39
TDP1 Q9NUW8 3/20 0.38
TSHR P16473 2/20 0.38
MAPK1 P28482 1/20 0.38
ATM Q13315 1/20 0.38
ALDH1A1 P00352 4/20 0.38
VCAM1 P19320 3/20 0.38
CYP3A4 P08684 2/20 0.38
HIF1A Q16665 2/20 0.37
MAPT P10636 1/20 0.37
HPGD P15428 1/20 0.36
ALOX15 P16050 1/20 0.36
TXNRD1 Q16881 1/20 0.36
TXNRD3 Q86VQ6 1/20 0.36
TXNRD2 Q9NNW7 1/20 0.36
PMM2 O15305 1/20 0.35
MPI P34949 1/20 0.35
PHOSPHO1 Q8TCT1 1/20 0.35
SRC P12931 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9050390 0.85 GPR35 (0.43) GPR35SLC6A4TDP1TSHRMAPK1
SCHEMBL7744957 0.82 VCAM1 (0.38) GPR35SLC6A4TDP1TSHRMAPK1
SCHEMBL7744960 0.82 VCAM1 (0.38) GPR35SLC6A4TDP1TSHRMAPK1
SCHEMBL138641 0.77 TDP1 (0.50) GPR35SLC6A4TDP1TSHRMAPK1
SCHEMBL30953155 0.77 TDP1 (0.50) GPR35SLC6A4TDP1TSHRMAPK1
SCHEMBL9694173 0.77 TSHR (0.50) GPR35SLC6A4TDP1TSHRMAPK1
SCHEMBL31094742 0.77 VCAM1 (0.40) GPR35TDP1TSHRMAPK1ATM
SCHEMBL309310 0.77 ALDH1A1 (0.49) GPR35SLC6A4TDP1TSHRMAPK1
SCHEMBL7750957 0.75 ALDH1A1 (0.42) SLC6A4TDP1MAPK1ALDH1A1VCAM1
SCHEMBL27759780 0.74 KDM4A (0.41) GPR35SLC6A4TDP1TSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-8268974-A None JP disclosed
JP-H08268974-A 3-FLUORO-4-CHLORO-6-NITROBENZALDEHYDE, 3-FLUORO-4-CHLORO-6-NITROBENZALDEHYDE ACETAL AND THEIR PRODUCTION UBE IND LTD 1996-10-15 JP disclosed