Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 18/20 | 0.53 |
| ▸ | DRD2 | P14416 | 5/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7926754 | 0.80 | HTR1A (0.55) | HTR1ADRD2HTR2A | |
| SCHEMBL9372184 | 0.78 | HTR2A (0.42) | HTR1ADRD2HTR2A | |
| SCHEMBL7926481 | 0.78 | HTR1A (0.46) | HTR1ADRD2HTR2A | |
| SCHEMBL8900041 | 0.77 | HTR1A (0.43) | HTR1AHTR2A | |
| SCHEMBL9052842 | 0.75 | DRD2 (0.45) | HTR1ADRD2 | |
| SCHEMBL7935755 | 0.73 | HTR1A (0.52) | HTR1A | |
| SCHEMBL6858888 | 0.73 | HTR2A (0.42) | DRD2HTR2A | |
| SCHEMBL7926747 | 0.72 | HTR2A (0.49) | HTR1ADRD2HTR2A | |
| SCHEMBL7935873 | 0.71 | MTNR1A (0.43) | HTR1ADRD2 | |
| SCHEMBL11456762 | 0.70 | HTR2A (0.42) | HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331636-B1 | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, DIABETES, HYPERTENSION, IMPOTENCY, APPETITE CONTROL | THE UPJOHN COMPANY | 2001-12-18 | — | — | US | disclosed |
| US-5545755-A | USEFUL TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS, HYPERTENSION, DIABETES, SEXUAL IMPOTENCY AND TO CONTROL APPETITE | THE UPJOHN COMPANY (US) | 1996-08-13 | — | — | US | disclosed |
| EP-0552246-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 1993-07-28 | — | — | EP | disclosed |
| WO-1992006967-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-04-30 | — | — | WO | disclosed |
| EP-0476016-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 1992-03-25 | — | — | EP | disclosed |
| WO-1990015047-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1990-12-13 | — | — | WO | disclosed |