Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ALPG | P10696 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9053622 | 0.85 | DRD2 (0.50) | SMN1; SMN2KDM4ELMNAPOLBMAPT | |
| SCHEMBL8545748 | 0.85 | ALDH1A1 (0.54) | SMN1; SMN2KDM4EALDH1A1LMNAPOLB | |
| SCHEMBL9052649 | 0.83 | DRD2 (0.54) | SMN1; SMN2KDM4EALDH1A1LMNATDP1 | |
| SCHEMBL8544972 | 0.82 | DRD2 (0.56) | DRD2DRD3 | |
| SCHEMBL9053373 | 0.81 | DRD2 (0.50) | SMN1; SMN2KDM4EALDH1A1LMNATDP1 | |
| SCHEMBL8544314 | 0.81 | MAPT (0.54) | SMN1; SMN2KDM4EALDH1A1POLBHTT | |
| SCHEMBL8540116 | 0.81 | L3MBTL1 (0.55) | SMN1; SMN2KDM4EALDH1A1MAPTGAA | |
| SCHEMBL8542006 | 0.79 | DRD2 (0.50) | ALDH1A1DRD2DRD3 | |
| SCHEMBL8540314 | 0.78 | POLB (0.47) | SMN1; SMN2KDM4EALDH1A1POLBMAPT | |
| SCHEMBL7569525 | 0.78 | DRD2 (0.49) | DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734378-A1 | AMINOSULPHONYL-PHENYL-1H-PYRROLE DERIVATIVES, METHOD OF THEIR PREPARATION AND THEIR USE | SMITHKLINE BEECHAM PLC (GB) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995016674-A1 | AMINOSULPHONYL-PHENYL-1H-PYRROLE DERIVATIVES, METHOD OF THEIR PREPARATION AND THEIR USE | SMITHKLINE BEECHAM PLC (GB) | 1995-06-22 | — | — | WO | disclosed |