Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540116 | 0.90 | L3MBTL1 (0.55) | ALDH1A1MAPTKDM4EDRD2DRD3 | |
| SCHEMBL9052649 | 0.90 | DRD2 (0.54) | ALDH1A1KDM4EDRD2DRD3SMN1; SMN2 | |
| SCHEMBL9053369 | 0.89 | DRD2 (0.52) | ALDH1A1MAPTKDM4EDRD2DRD3 | |
| SCHEMBL8544314 | 0.86 | MAPT (0.54) | ALDH1A1MAPTKDM4EDRD2DRD3 | |
| SCHEMBL9053438 | 0.85 | SMN1; SMN2 (0.51) | ALDH1A1MAPTKDM4EDRD2DRD3 | |
| SCHEMBL8544972 | 0.84 | DRD2 (0.56) | DRD2DRD3 | |
| SCHEMBL9053373 | 0.81 | DRD2 (0.50) | ALDH1A1MAPTKDM4EDRD2DRD3 | |
| SCHEMBL9053622 | 0.81 | DRD2 (0.50) | MAPTKDM4EDRD2DRD3SMN1; SMN2 | |
| SCHEMBL9053039 | 0.79 | PGR (0.51) | ALDH1A1MAPTKDM4ECYP1A2CYP3A4 | |
| SCHEMBL8540314 | 0.78 | POLB (0.47) | ALDH1A1MAPTKDM4EDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705259-B1 | PHENYRROLE DERIVATIVES AND THEIR USE AS DOPAMINE D3 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-02-25 | — | — | EP | disclosed |
| EP-0705259-A1 | PHENYRROLE DERIVATIVES AND THEIR USE AS DOPAMINE D3 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-04-10 | — | — | EP | disclosed |
| WO-1995000508-A1 | PHENYRROLE DERIVATIVES AND THEIR USE AS DOPAMINE D3 ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-01-05 | — | — | WO | disclosed |