Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.45 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9052649 | 0.88 | DRD2 (0.54) | DRD2DRD3ALDH1A1POLBHTT | |
| SCHEMBL8544314 | 0.84 | MAPT (0.54) | DRD2DRD3ALDH1A1POLBHTT | |
| SCHEMBL9053622 | 0.84 | DRD2 (0.50) | DRD2DRD3HTR2CPOLBKDM4E | |
| SCHEMBL8542006 | 0.82 | DRD2 (0.50) | DRD2DRD3ALDH1A1 | |
| SCHEMBL8545748 | 0.81 | ALDH1A1 (0.54) | DRD2DRD3ALDH1A1POLBRXFP1 | |
| SCHEMBL9053438 | 0.81 | SMN1; SMN2 (0.51) | DRD2DRD3ALDH1A1POLBHTT | |
| SCHEMBL8540314 | 0.79 | POLB (0.47) | DRD2DRD3ALDH1A1POLBHPGD | |
| SCHEMBL8540116 | 0.79 | L3MBTL1 (0.55) | DRD2DRD3ALDH1A1KDM4EMAPT | |
| SCHEMBL9054157 | 0.79 | DRD2 (0.41) | DRD2DRD3ALDH1A1HPGDLMNA | |
| SCHEMBL9053369 | 0.78 | DRD2 (0.52) | DRD2DRD3ALDH1A1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734378-A1 | AMINOSULPHONYL-PHENYL-1H-PYRROLE DERIVATIVES, METHOD OF THEIR PREPARATION AND THEIR USE | SMITHKLINE BEECHAM PLC (GB) | 1996-10-02 | — | — | EP | disclosed |
| WO-1995016674-A1 | AMINOSULPHONYL-PHENYL-1H-PYRROLE DERIVATIVES, METHOD OF THEIR PREPARATION AND THEIR USE | SMITHKLINE BEECHAM PLC (GB) | 1995-06-22 | — | — | WO | disclosed |