Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | GAA | P10253 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 6/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9152818 | 0.85 | ALDH1A1 (0.30) | ALDH1A1MAPTTDP1KCNH2 | |
| SCHEMBL9054112 | 0.77 | POLB (0.30) | POLB | |
| SCHEMBL9145266 | 0.67 | ALDH1A1 (0.47) | ALDH1A1GAAMAPTNPSR1POLB | |
| SCHEMBL9054381 | 0.67 | ALDH1A1 (0.44) | ALDH1A1GAAMAPTNPSR1POLB | |
| SCHEMBL9053850 | 0.66 | LMNA (0.48) | ALDH1A1GAAMAPTNPSR1POLB | |
| SCHEMBL11812673 | 0.66 | ALDH1A1 (0.30) | ALDH1A1 | |
| SCHEMBL9495401 | 0.66 | ALDH1A1 (0.32) | ALDH1A1GAAMAPTLMNA | |
| SCHEMBL9495397 | 0.66 | ALDH1A1 (0.32) | ALDH1A1GAAMAPTLMNA | |
| SCHEMBL9053704 | 0.65 | — | — | |
| SCHEMBL9053600 | 0.62 | LMNA (0.35) | ALDH1A1GAAMAPTNPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0508955-B1 | Use of 2-iminothiazolidin-4-one derivatives as new medicaments | CIBA GEIGY AG (CH) | 1996-06-19 | — | — | EP | claimed |
| EP-0508955-A1 | Use of 2-iminothiazolidin-4-one derivatives as new medicaments | CIBA-GEIGY AG (CH) | 1992-10-14 | — | — | EP | claimed |
| EP-0508955-B1 | Use of 2-iminothiazolidin-4-one derivatives as new medicaments | CIBA GEIGY AG (CH) | 1996-06-19 | — | — | EP | disclosed |
| US-5399576-A | Rheumatic diseases | CIBA-GEIGY CORPORATION (US) | 1995-03-21 | — | — | US | disclosed |
| US-5378719-A | Antiarthritic agents; rheumatic diseases | CIBA-GEIGY CORPORATION (US) | 1995-01-03 | — | — | US | disclosed |
| US-5229405-A | Rheumatic diseases | CIBA-GEIGY CORPORATION (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0548018-A1 | Imidazoles | CIBA-GEIGY AG (CH) | 1993-06-23 | — | — | EP | disclosed |
| EP-0548017-A1 | Thiazoles | CIBA-GEIGY AG (CH) | 1993-06-23 | — | — | EP | disclosed |
| EP-0508955-A1 | Use of 2-iminothiazolidin-4-one derivatives as new medicaments | CIBA-GEIGY AG (CH) | 1992-10-14 | — | — | EP | disclosed |