Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.35 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.35 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9053830 | 0.93 | AKR1B1 (0.35) | AKR1B1FTOCYP26A1CYP26B1CYP3A4 | |
| SCHEMBL15867091 | 0.85 | FTO (0.38) | AKR1B1FTOCYP26A1CYP26B1TSHR | |
| SCHEMBL9054609 | 0.76 | CYP26A1 (0.35) | AKR1B1FTOCYP26A1CYP26B1ALDH1A1 | |
| SCHEMBL9054260 | 0.74 | MAPT (0.42) | AKR1B1MAPK1CTSDBACE1ALDH1A1 | |
| SCHEMBL9054386 | 0.74 | MAPT (0.42) | AKR1B1FTOCYP26A1CYP26B1MAPK1 | |
| SCHEMBL9053228 | 0.72 | RARA (0.38) | CYP26A1CYP26B1CYP3A4TSHRMAPK1 | |
| SCHEMBL8561808 | 0.72 | AKR1B1 (0.33) | AKR1B1FTOCYP26A1CYP26B1 | |
| SCHEMBL7224925 | 0.72 | RXRA (0.42) | AKR1B1FTOCYP26A1CYP26B1 | |
| SCHEMBL7224928 | 0.72 | CYP26A1 (0.35) | AKR1B1FTOCYP26A1CYP26B1ALDH1A1 | |
| SCHEMBL7218162 | 0.71 | CYP26A1 (0.42) | AKR1B1FTOCYP26A1CYP26B1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5498755-A | IMINE COMPOUNDS FOR SKIN DISORDERS AND ANTIINFLAMMATORY AGENTS | ALLERGAN, INC. | 1996-03-12 | — | — | US | disclosed |
| WO-1996006070-A1 | DISUBSTITUTED ARYL AND HETEROARYL IMINES HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY | ALLERGAN (US) | 1996-02-29 | — | — | WO | disclosed |