Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ABCC9 | O60706 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9394843 | 0.91 | KCNE1 (0.40) | HSD11B1SLC6A2SLC6A4ABCC9ALDH1A1 | |
| SCHEMBL9050651 | 0.88 | ABCC9 (0.40) | HSD11B1SLC6A2SLC6A4ABCC9 | |
| SCHEMBL9049722 | 0.88 | ABCC9 (0.40) | HSD11B1SLC6A2SLC6A4ABCC9 | |
| SCHEMBL9397011 | 0.84 | ABCC9 (0.44) | ABCC9LMNA | |
| SCHEMBL9050314 | 0.80 | SLC6A2 (0.42) | HSD11B1SLC6A2SLC6A4ALDH1A1MEN1 | |
| SCHEMBL9048915 | 0.79 | ABCC9 (0.49) | HSD11B1SLC6A2SLC6A4ABCC9ALDH1A1 | |
| SCHEMBL8883144 | 0.75 | HSD11B1 (0.40) | HSD11B1SLC6A2SLC6A4ALDH1A1KDM4E | |
| SCHEMBL8085045 | 0.72 | ABCC9 (0.42) | ABCC9ALDH1A1KDM4EMEN1GAA | |
| SCHEMBL9397103 | 0.72 | SLC6A2 (0.39) | HSD11B1SLC6A2SLC6A4ALDH1A1MEN1 | |
| SCHEMBL9394870 | 0.72 | ABCC9 (0.42) | ABCC9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690855-A1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LTD (GB) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994020491-A1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |