Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9057016 | 0.93 | MAPT (0.43) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9056076 | 0.90 | MAPT (0.50) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9053052 | 0.73 | L3MBTL1 (0.39) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9042425 | 0.72 | GAA (0.41) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8555699 | 0.69 | L3MBTL1 (0.47) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8046948 | 0.68 | ALDH1A1 (0.72) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL11107385 | 0.67 | ALDH1A1 (0.60) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL8036213 | 0.66 | ALDH1A1 (0.53) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL1613761 | 0.66 | MAPT (0.65) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9734800 | 0.65 | MAPT (0.56) | MAPTALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0553130-B1 | PYRROLIDINE DIONE DERIVATIVES | PFIZER (US) | 1996-01-03 | — | — | EP | disclosed |
| EP-0553130-A1 | PYRROLIDINE DIONE DERIVATIVES. | PFIZER (US) | 1993-08-04 | — | — | EP | disclosed |
| WO-1992006954-A2 | PYRROLIDINE DIONE DERIVATIVES | PFIZER INC. (US) | 1992-04-30 | — | — | WO | disclosed |