Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.49 |
| ▸ | DHFR | P00374 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11191975 | 0.83 | ALOX5 (0.50) | ALOX5PTGS1PTGS2PRKCZDHFR | |
| SCHEMBL907869 | 0.81 | PRKCZ (0.45) | ALOX5PRKCZDHFRNOTUMMEN1 | |
| SCHEMBL11188275 | 0.81 | PRKCZ (0.56) | ALOX5PTGS1PTGS2PRKCZDHFR | |
| SCHEMBL908054 | 0.78 | PRKCZ (0.45) | ALOX5PRKCZDHFRALDH1A1HTR3E | |
| SCHEMBL7721905 | 0.77 | L3MBTL1 (0.40) | ALOX5PRKCZALDH1A1SIGMAR1MAPT | |
| SCHEMBL10918593 | 0.72 | ALOX5 (0.57) | ALOX5PTGS1PTGS2PRKCZDHFR | |
| SCHEMBL7719321 | 0.71 | PRKCZ (0.40) | PTGS2PRKCZDHFRALDH1A1MAPT | |
| Bw-755C SCHEMBL30088397 | 0.70 | ALOX5 (1.00) | ALOX5PTGS1PTGS2DHFRALDH1A1 | |
| Bw-755C SCHEMBL2573191 | 0.70 | ALOX5 (1.00) | ALOX5PTGS1PTGS2DHFRALDH1A1 | |
| SCHEMBL11059805 | 0.69 | MEN1 (0.41) | PTGS2DHFRALDH1A1MAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110003862-A1 | 3-Animopyraolines for Treatment of Neurodegenerative and Psychiatric Diseases | MERCK SHARP & DOHME LIMITED (GB) | 2011-01-06 | — | — | US | claimed |
| EP-1987007-A1 | 3-AMINOPYRAZOLINES FOR TREATMENT OF NEURODEGENERATIVE AND PSYCHIATRIC DISEASES | MERCK SHARP & DOHME LTD. (GB) | 2008-11-05 | — | — | EP | claimed |
| WO-2007093829-A1 | 3-AMINOPYRAZOLINES FOR TREATMENT OF NEURODEGENERATIVE AND PSYCHIATRIC DISEASES | MERCK SHARP & DOHME LIMITED (GB) | 2007-08-23 | — | — | WO | claimed |
| US-20110003862-A1 | 3-Animopyraolines for Treatment of Neurodegenerative and Psychiatric Diseases | MERCK SHARP & DOHME LIMITED (GB) | 2011-01-06 | — | — | US | disclosed |
| EP-1987007-A1 | 3-AMINOPYRAZOLINES FOR TREATMENT OF NEURODEGENERATIVE AND PSYCHIATRIC DISEASES | MERCK SHARP & DOHME LTD. (GB) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093829-A1 | 3-AMINOPYRAZOLINES FOR TREATMENT OF NEURODEGENERATIVE AND PSYCHIATRIC DISEASES | MERCK SHARP & DOHME LIMITED (GB) | 2007-08-23 | — | — | WO | disclosed |
| EP-0070376-A1 | Heterocyclic substituted-amino-pyrazolines | AMERICAN CYANAMID COMPANY (US) | 1983-01-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003862-A1 | 3-Animopyraolines for Treatment of Neurodegenerative and Psychiatric Diseases | DAO, DDO, MAOA | ALOX5 1140/4885PTGS1 1991/4885PTGS2 2364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.