Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 11/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 3/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9096567 | 0.77 | PKM (0.46) | GAAMAPTCA12CA1CA2 | |
| SCHEMBL7218139 | 0.72 | IDO1 (0.38) | MAOB | |
| SCHEMBL164001 | 0.69 | TDP1 (0.50) | GAASMN1; SMN2KMT2ATDP1MAOB | |
| SCHEMBL9094464 | 0.69 | CA2 (0.51) | DRD3GAAMAPTCA12CA1 | |
| SCHEMBL4195064 | 0.69 | MAPT (0.42) | GAAMAPTCA2ALDH1A1HSD17B10 | |
| SCHEMBL4195063 | 0.69 | MAPT (0.42) | GAAMAPTCA2ALDH1A1HSD17B10 | |
| SCHEMBL4434740 | 0.67 | DRD3 (0.51) | DRD3GAAMAPTCA12CA1 | |
| SCHEMBL11265304 | 0.67 | MAPT (0.41) | GAAMAPTCA2ALDH1A1HSD17B10 | |
| SCHEMBL20401785 | 0.66 | ALDH1A1 (0.41) | DRD3GAAMAPTCA12CA1 | |
| SCHEMBL242386 | 0.66 | DRD3 (0.47) | DRD3GAAMAPTCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5498621-A | Oxazolidinedione hypoglycemic agents | PFIZER INC. (US) | 1996-03-12 | — | — | US | disclosed |
| EP-0428312-B1 | Oxazolidinedione hypoglycemic agents | PFIZER (US) | 1994-12-28 | — | — | EP | disclosed |
| WO-1991007107-A1 | OXAZOLIDINEDIONE HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1991-05-30 | — | — | WO | disclosed |
| EP-0428312-A2 | Oxazolidinedione hypoglycemic agents | PFIZER INC. (US) | 1991-05-22 | — | — | EP | disclosed |