Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MIF | P14174 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL156029 | 0.97 | TSHR (0.52) | TRPA1TSHRMIFTAAR1KDM4E | |
| SCHEMBL198507 | 0.97 | TSHR (0.52) | TRPA1TSHRMIFTAAR1KDM4E | |
| SCHEMBL7039581 | 0.97 | TSHR (0.52) | TRPA1TSHRMIFTAAR1KDM4E | |
| SCHEMBL28208618 | 0.97 | TSHR (0.52) | TRPA1TSHRMIFTAAR1KDM4E | |
| SCHEMBL954845 | 0.84 | PTGS2 (0.48) | TRPA1TSHRALDH1A1 | |
| SCHEMBL6565095 | 0.84 | ESR1 (0.43) | TRPA1TSHRALDH1A1AKR1C3AKR1C1 | |
| SCHEMBL11144946 | 0.82 | PBRM1 (0.45) | TRPA1TSHRTAAR1KDM4EADRA2A | |
| SCHEMBL5324135 | 0.82 | PTGS2 (0.56) | TSHRKDM4ECYP2D6LMNAHIF1A | |
| SCHEMBL28153074 | 0.82 | TRPA1 (0.39) | TRPA1TSHRTAAR1KDM4ELMNA | |
| SCHEMBL9079901 | 0.79 | CTSK (0.48) | TRPA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2072515-B1 | Substituted quinazolidines for antidiabetic treatment | 55PHARMA DRUG DISCOVERY & DEV AG (AT) | 2011-08-31 | — | — | EP | disclosed |
| US-20110003808-A1 | OCTAHYDROQUINOLIZINES FOR ANTIDIABETIC TREATMENT | 55PHARMA DRUG DISCOVERY & DEVELOPMENT AG (AT) | 2011-01-06 | — | — | US | disclosed |
| EP-2222673-A1 | OCTAHYDROQUINOLI ZINES FOR ANTIDIABETIC TREATMENT | 55pharma Drug Discovery & Development AG (AT) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009076693-A1 | OCTAHYDROQUINOLI ZINES FOR ANTIDIABETIC TREATMENT | 55PHARMA DRUG DISCOVERY & DEVELOPMENT AG (AT) | 2009-06-25 | — | — | WO | disclosed |
| EP-2072515-A1 | Substituted quinazolidines for antidiabetic treatment | 55pharma Drug Discovery & Development AG (AT) | 2009-06-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003808-A1 | OCTAHYDROQUINOLIZINES FOR ANTIDIABETIC TREATMENT | GPR119, LIPC, GLP1R | TRPA1 2821/4885TSHR 2069/4885MIF 3171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.