Nymphaeol A

Nymphaeol A

SCHEMBL909988

CC(C)=CCC/C(C)=C/Cc1c(O)cc2c(c1O)C(=O)CC(c1ccc(O)c(O)c1)O2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ELANE P08246 8/20 1.00
ACHE P22303 4/20 1.00
PTGS2 P35354 4/20 1.00
ALOX5 P09917 3/20 1.00
TP53 P04637 1/20 0.84
MDM2 Q00987 1/20 0.84
PTPN1 P18031 1/20 0.72
CACNA1H O95180 2/20 0.69
CACNA1G O43497 1/20 0.69
ESR1 P03372 1/20 0.69
MAPT P10636 1/20 0.69
MAPK1 P28482 1/20 0.69
KMT2A Q03164 1/20 0.69
ATM Q13315 1/20 0.69
NPSR1 Q6W5P4 1/20 0.69
PDE4D Q08499 1/20 0.65
ABCG2 Q9UNQ0 1/20 0.64
PLA2G1B P04054 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nymphaeol A SCHEMBL16105856 1.00 ELANE (1.00) ELANEACHEPTGS2ALOX5TP53
Nymphaeol A SCHEMBL30637584 1.00 ELANE (1.00) ELANEACHEPTGS2ALOX5TP53
Nymphaeol A SCHEMBL7795014 1.00 ELANE (1.00) ELANEACHEPTGS2ALOX5TP53
Nymphaeol A SCHEMBL30532526 1.00 ELANE (1.00) ELANEACHEPTGS2ALOX5TP53
Nymphaeol A SCHEMBL909992 1.00 ELANE (1.00) ELANEACHEPTGS2ALOX5TP53
SCHEMBL16105743 0.99 ELANE (0.98) ELANEACHEPTGS2ALOX5TP53
SCHEMBL3238475 0.99 ELANE (0.98) ELANEACHEPTGS2ALOX5TP53
SCHEMBL12909498 0.99 ELANE (0.98) ELANEACHEPTGS2ALOX5TP53
SCHEMBL26621041 0.93 ELANE (0.86) ELANEACHEPTGS2ALOX5TP53
SCHEMBL13043321 0.93 ELANE (0.86) ELANEACHEPTGS2ALOX5TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3946271-B1 METHOD OF PRODUCTION OF A COMPOSITE OF YEAST-DERIVED BETA GLUCAN PARTICLE WITH INCORPORATED POORLY-WATER-SOLUBLE LOW-MOLECULAR-WEIGHT COMPOUND, PHARMACEUTICAL PREPARATION AND USE THEREOF VS CHEMICKO TECHNOLOGICKA V PRAZE (CZ) 2024-12-25 EP claimed
US-20220192985-A1 METHOD OF PRODUCTION OF A COMPOSITE OF YEAST-DERIVED BETA GLUCAN PARTICLE WITH INCORPORATED POORLY-WATER-SOLUBLE LOW-MOLECULAR-WEIGHT COMPOUND, PHARMACEUTICAL PREPARATION AND USE THEREOF VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE (CZ) 2022-06-23 US claimed
EP-3946271-A1 METHOD OF PRODUCTION OF A COMPOSITE OF YEAST-DERIVED BETA GLUCAN PARTICLE WITH INCORPORATED POORLY-WATER-SOLUBLE LOW-MOLECULAR-WEIGHT COMPOUND, PHARMACEUTICAL PREPARATION AND USE THEREOF Vysoká skola chemicko-technologická v Praze (CZ) 2022-02-09 EP claimed
WO-2020200337-A1 METHOD OF PRODUCTION OF A COMPOSITE OF YEAST-DERIVED BETA GLUCAN PARTICLE WITH INCORPORATED POORLY-WATER-SOLUBLE LOW-MOLECULAR-WEIGHT COMPOUND, PHARMACEUTICAL PREPARATION AND USE THEREOF VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE (CZ) 2020-10-08 WO claimed
CN-101883574-B Periodontal bacterial growth inhibitor, oral hygiene product, and food and drink POKKA CORP 2013-06-26 CN claimed
US-20250381166-A1 Cannabis-Derived Flavonoids And Related Methods CANURTA INC (CA) 2025-12-18 US disclosed
US-12485105-B2 Composition for suppressing obesity DAICEL CORPORATION (JP) 2025-12-02 US disclosed
EP-3946271-B1 METHOD OF PRODUCTION OF A COMPOSITE OF YEAST-DERIVED BETA GLUCAN PARTICLE WITH INCORPORATED POORLY-WATER-SOLUBLE LOW-MOLECULAR-WEIGHT COMPOUND, PHARMACEUTICAL PREPARATION AND USE THEREOF VS CHEMICKO TECHNOLOGICKA V PRAZE (CZ) 2024-12-25 EP disclosed
WO-2023141695-A1 CANNABIS-DERIVED FLAVONOIDS AND RELATED METHODS CANURTA INC. (CA) 2023-08-03 WO disclosed
US-20230040395-A1 COMPOSITION FOR SUPPRESSING OBESITY DAICEL CORPORATION (JP) 2023-02-09 US disclosed
EP-4079302-A1 COMPOSITION FOR SUPPRESSING OBESITY Daicel Corporation (JP) 2022-10-26 EP disclosed
US-20220192985-A1 METHOD OF PRODUCTION OF A COMPOSITE OF YEAST-DERIVED BETA GLUCAN PARTICLE WITH INCORPORATED POORLY-WATER-SOLUBLE LOW-MOLECULAR-WEIGHT COMPOUND, PHARMACEUTICAL PREPARATION AND USE THEREOF VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE (CZ) 2022-06-23 US disclosed
EP-2186806-A1 Flavanone compound and uses thereof POKKA CORPORATION (JP) 2010-05-19 EP disclosed
EP-1640371-A4 FLAVANONE COMPOUND AND USES THEREOF POKKA CORP (JP) 2009-06-10 EP disclosed
US-7256214-B2 5,7,3',4'-Tetrahydroxy-5'-C-geranylflavanone (isonymphaeol-B), isolated from an Okinawa propolis; microbiocide, antitumor agent, food, beverage and cosmetic preservative; antioxidant food supplement POKKA CORPORATION (JP) 2007-08-14 US disclosed
US-20070161579-A1 FLAVANONE COMPOUND AND USES THEREOF POKKA CORPORATION (JP) 2007-07-12 US disclosed
JP-2007039365-A METHOD FOR PRODUCING EXTRACT OF MACARANGA TANARIUM POKKA CORP 2007-02-15 JP disclosed
US-20060292204-A1 Flavanone compound and uses thereof POKKA CORPORATION (JP) 2006-12-28 US disclosed
EP-1640371-A1 FLAVANONE COMPOUND AND USES THEREOF POKKA CORPORATION (JP) 2006-03-29 EP disclosed
US-20050152996-A1 Extracts of Mimulus aurantiacus for treating psoriasis and repelling insects BUTLER Donald (US) 2005-07-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230040395-A1 COMPOSITION FOR SUPPRESSING OBESITY FABP4, SREBF1, GPR119 ELANE 2436/4885ACHE 4250/4885PTGS2 533/4885
US-20070161579-A1 FLAVANONE COMPOUND AND USES THEREOF NQO1, GPX4, NDUFV2 ELANE 501/4885ACHE 565/4885PTGS2 2072/4885
US-12485105-B2 Composition for suppressing obesity FABP4, SREBF1, GPR119 ELANE 2436/4885ACHE 4250/4885PTGS2 533/4885
US-20060292204-A1 Flavanone compound and uses thereof NQO1, GPX4, NDUFV2 ELANE 501/4885ACHE 565/4885PTGS2 2072/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.