Nymphaeol A

Nymphaeol A

SCHEMBL7795014

CC(C)=CCC/C(C)=C/Cc1c(O)cc2c(c1O)C(=O)C[C@@H](c1ccc(O)c(O)c1)O2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ELANE P08246 8/20 1.00
ACHE P22303 4/20 1.00
PTGS2 P35354 4/20 1.00
ALOX5 P09917 3/20 1.00
TP53 P04637 1/20 0.84
MDM2 Q00987 1/20 0.84
PTPN1 P18031 1/20 0.72
CACNA1H O95180 2/20 0.69
CACNA1G O43497 1/20 0.69
ESR1 P03372 1/20 0.69
MAPT P10636 1/20 0.69
MAPK1 P28482 1/20 0.69
KMT2A Q03164 1/20 0.69
ATM Q13315 1/20 0.69
NPSR1 Q6W5P4 1/20 0.69
PDE4D Q08499 1/20 0.65
ABCG2 Q9UNQ0 1/20 0.64
PLA2G1B P04054 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nymphaeol A SCHEMBL16105856 1.00 ELANE (1.00) ELANEACHEPTGS2ALOX5TP53
Nymphaeol A SCHEMBL909988 1.00 ELANE (1.00) ELANEACHEPTGS2ALOX5TP53
Nymphaeol A SCHEMBL30637584 1.00 ELANE (1.00) ELANEACHEPTGS2ALOX5TP53
Nymphaeol A SCHEMBL30532526 1.00 ELANE (1.00) ELANEACHEPTGS2ALOX5TP53
Nymphaeol A SCHEMBL909992 1.00 ELANE (1.00) ELANEACHEPTGS2ALOX5TP53
SCHEMBL16105743 0.99 ELANE (0.98) ELANEACHEPTGS2ALOX5TP53
SCHEMBL3238475 0.99 ELANE (0.98) ELANEACHEPTGS2ALOX5TP53
SCHEMBL12909498 0.99 ELANE (0.98) ELANEACHEPTGS2ALOX5TP53
SCHEMBL26621041 0.93 ELANE (0.86) ELANEACHEPTGS2ALOX5TP53
SCHEMBL13043321 0.93 ELANE (0.86) ELANEACHEPTGS2ALOX5TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2783684-B1 PRENYLFLAVANONE COMPOUNDS FOR MODULATING DIABETES NATUREWISE BIOTECH & MEDICALS CORP (TW) 2018-10-03 EP claimed
US-9457007-B2 Prenylflavanone compounds for modulating diabetes NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) 2016-10-04 US claimed
US-20140296543-A1 PRENYLFLAVANONE COMPOUNDS FOR MODULATING DIABETES NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) 2014-10-02 US claimed
EP-2783684-A1 Prenylflavanone compounds for modulating diabetes NatureWise Biotech & Medicals Corporation (TW) 2014-10-01 EP claimed
EP-4577181-A1 ORAL CARE COMPOSITIONS Adyani Consulting Corp. (US) 2025-07-02 EP disclosed
WO-2024042191-A1 ORAL CARE COMPOSITIONS BLISSANDMORE GMBH (DE) 2024-02-29 WO disclosed
US-11795127-B2 Processes for the preparation of ortho-allylated hydroxy aryl compounds MCMASTER UNIVERSITY (CA) 2023-10-24 US disclosed
US-20230113567-A1 PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS MCMASTER UNIVERSITY (CA) 2023-04-13 US disclosed
CN-115038435-A Composition for obesity inhibition 株式会社大赛璐 2022-09-09 CN disclosed
US-20210380513-A1 PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS MCMASTER UNIVERSITY (CA) 2021-12-09 US disclosed
WO-2021237371-A1 PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS MCMASTER UNIVERSITY (CA) 2021-12-02 WO disclosed
EP-3261635-B1 BENZENE COMPOUNDS FOR TREATING OCULAR DISEASES NATUREWISE BIOTECH & MEDICALS CORP (TW) 2021-03-31 EP disclosed
US-20100144857-A1 PRENYLFLAVANONE COMPOUNDS AND USES THEREOF NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) 2010-06-10 US disclosed
US-20100144857-A1 PRENYLFLAVANONE COMPOUNDS AND USES THEREOF NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) 2010-06-10 US disclosed
US-7585892-B2 Compound for promoting the growth of neural cells NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) 2009-09-08 US disclosed
US-7585892-B2 Compound for promoting the growth of neural cells NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) 2009-09-08 US disclosed
US-20090076130-A1 COMPOUNDS FOR THE INHIBITION OF HISTONE DEACETYLASE NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) 2009-03-19 US disclosed
US-20090076130-A1 COMPOUNDS FOR THE INHIBITION OF HISTONE DEACETYLASE NATUREWISE BIOTECH & MEDICALS CORPORATION (TW) 2009-03-19 US disclosed
US-20070232534-A1 Promote the growth of neurons, which is revealed by the increase in the thickness, length and number of branches in the neurites; stimulating the proliferation of neuron stem cells using propolin NATUREWISE BIOTECH& MEDICALS CORPORATION (TW) 2007-10-04 US disclosed
US-20070232534-A1 Promote the growth of neurons, which is revealed by the increase in the thickness, length and number of branches in the neurites; stimulating the proliferation of neuron stem cells using propolin NATUREWISE BIOTECH& MEDICALS CORPORATION (TW) 2007-10-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230113567-A1 PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS ADH1A, ADH1C, AHR ELANE 1548/4885ACHE 2560/4885PTGS2 2381/4885
US-20100144857-A1 PRENYLFLAVANONE COMPOUNDS AND USES THEREOF FNTA, CYP4F2, CYP4F3 ELANE 1512/4885ACHE 3450/4885PTGS2 599/4885
US-20210380513-A1 PROCESSES FOR THE PREPARATION OF ORTHO-ALLYLATED HYDROXY ARYL COMPOUNDS ADH1A, ADH1C, AHR ELANE 1548/4885ACHE 2560/4885PTGS2 2381/4885
US-11795127-B2 Processes for the preparation of ortho-allylated hydroxy aryl compounds ADH1A, ADH1C, AHR ELANE 1548/4885ACHE 2560/4885PTGS2 2381/4885
US-20140296543-A1 PRENYLFLAVANONE COMPOUNDS FOR MODULATING DIABETES SREBF2, GID4, SREBF1 ELANE 3443/4885ACHE 4566/4885PTGS2 559/4885
US-20090076130-A1 COMPOUNDS FOR THE INHIBITION OF HISTONE DEACETYLASE SMN1; SMN2, HDAC1, HDAC5 ELANE 1578/4885ACHE 913/4885PTGS2 3139/4885
US-20070232534-A1 Promote the growth of neurons, which is revealed by the increase in the thickness, length and number of branches in the neurites; stimulating the proliferation of neuron stem cells using propolin NGF, BDNF, DCX ELANE 3157/4885ACHE 159/4885PTGS2 266/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.