Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5474507 | 0.85 | MEN1 (0.48) | KMT2AMEN1HTTL3MBTL1HPGD | |
| SCHEMBL1000812 | 0.85 | MEN1 (0.48) | KMT2AMEN1HTTL3MBTL1HPGD | |
| SCHEMBL14717641 | 0.85 | MEN1 (0.48) | KMT2AMEN1HTTL3MBTL1HPGD | |
| SCHEMBL5065706 | 0.78 | KMT2A (0.47) | KMT2AMEN1HTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL14966043 | 0.77 | KMT2A (0.35) | KMT2AMEN1HTTL3MBTL1TSHR | |
| SCHEMBL6987291 | 0.75 | MTNR1A (0.42) | KMT2AMEN1HTTL3MBTL1ALDH1A1 | |
| SCHEMBL9820014 | 0.75 | MMP3 (0.41) | KMT2AMEN1HTTL3MBTL1ACE | |
| SCHEMBL15521836 | 0.75 | HPGD (0.41) | KMT2AMEN1HTTL3MBTL1HPGD | |
| SCHEMBL15521834 | 0.75 | HPGD (0.41) | KMT2AMEN1HTTL3MBTL1HPGD | |
| SCHEMBL27931947 | 0.74 | HPGD (0.44) | KMT2AMEN1HTTL3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120142668-A1 | CATHEPSIN C INHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120142668-A1 | CATHEPSIN C INHIBITORS | CTSE, CTSB, CTSS | KMT2A 4280/4885MEN1 4882/4885HTT 3677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.