Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6118398 | 0.77 | GAA (0.46) | GAA | |
| SCHEMBL6118180 | 0.75 | MEN1 (0.34) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL4324973 | 0.73 | KDM4E (0.68) | ALDH1A1KMT2AMEN1LMNANPSR1 | |
| SCHEMBL6117825 | 0.72 | KDM4E (0.54) | ALDH1A1KMT2AMEN1LMNANPSR1 | |
| SCHEMBL9103819 | 0.71 | LMNA (0.42) | ALDH1A1KMT2AMEN1LMNANPSR1 | |
| SCHEMBL9105339 | 0.69 | KMT2A (0.45) | ALDH1A1KMT2AMEN1LMNAMAPT | |
| SCHEMBL9105929 | 0.68 | MAPK1 (0.50) | ALDH1A1KMT2AMEN1LMNATSHR | |
| SCHEMBL26816572 | 0.67 | ALDH1A1 (0.61) | ALDH1A1KMT2AMEN1NPSR1MAPT | |
| SCHEMBL16200096 | 0.66 | MRGPRX4 (0.46) | ALDH1A1KMT2AMEN1MAPTKDM4E | |
| SCHEMBL16200085 | 0.65 | TAAR1 (0.50) | ALDH1A1NPSR1MAPTKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2669271-A1 | INDOLE DERIVATIVE, AND PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2013-12-04 | — | — | EP | disclosed |
| EP-2460791-A1 | INDOLE DERIVATIVE AND PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2012-06-06 | — | — | EP | disclosed |