Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.41 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12094843 | 0.84 | — | — | |
| SCHEMBL9823399 | 0.82 | L3MBTL1 (0.41) | HSD17B3L3MBTL1TDP1CES1 | |
| Butyric Acid SCHEMBL2453145 | 0.78 | FFAR3 (0.42) | L3MBTL1HCAR2CES2CES1 | |
| SCHEMBL19774130 | 0.77 | — | — | |
| SCHEMBL5162827 | 0.75 | NPC1 (0.39) | HPGDSMN1; SMN2ALDH1A1TSHRHSD17B10 | |
| SCHEMBL5160608 | 0.75 | RAB9A (0.39) | HPGDSMN1; SMN2L3MBTL1ALDH1A1TSHR | |
| SCHEMBL5160836 | 0.74 | KMT2A (0.35) | SMN1; SMN2L3MBTL1ALDH1A1RECQL | |
| SCHEMBL20488640 | 0.74 | ALDH1A1 (0.50) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL10839700 | 0.74 | MEN1 (0.35) | ALDH1A1 | |
| SCHEMBL5285523 | 0.73 | ALDH1A1 (0.47) | HPGDSMN1; SMN2L3MBTL1ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159558-A1 | SPIROTRICYCLE RIPK1 INHIBITORS AND METHODS OF USES THEREOF | MERCK SHARP & DOHME LLC (US) | 2023-05-25 | — | — | US | disclosed |
| US-5508202-A | MIXING SAMPLE AND FIBRIN PRECIPITATION INHIBITOR, ADDING THROMBIN SOLUTION, DETERMINING FIBRIN COAGULATION TIME IN PRESENCE OF CALCIUM ION, CAMPARING COAGULATION TIME WITH NORMAL COAGULATION TIME | NIPPON SHOJI KAISHA, LTD. (JP) | 1996-04-16 | — | — | US | disclosed |
| EP-0632270-A1 | METHOD OF ASSAYING ACTIVITY OF BLOOD COAGULATION FACTOR XIII AND REAGENT KIT THEREFOR | NIPPON SHOJI KABUSHIKI KAISHA (JP) | 1995-01-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230159558-A1 | SPIROTRICYCLE RIPK1 INHIBITORS AND METHODS OF USES THEREOF | RIPK1, RIPK3, RIPK4 | HSD17B3 1093/4885GABRA1 4773/4885GABRG2 4839/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.