Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.39 |
| ▸ | BAZ2A | Q9UIF9 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.37 |
| ▸ | MAP2K3 | P46734 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28070421 | 0.98 | BAZ2B (0.38) | BAZ2BBAZ2AMAPTL3MBTL1TSHR | |
| SCHEMBL17894085 | 0.86 | KDM4E (0.42) | BAZ2BBAZ2AMAPTL3MBTL1TSHR | |
| SCHEMBL1646369 | 0.85 | L3MBTL1 (0.35) | BAZ2BBAZ2AMAPTL3MBTL1CYP2C19 | |
| SCHEMBL31183044 | 0.79 | PTGS2 (0.35) | BAZ2BBAZ2AMAPTL3MBTL1CYP2C19 | |
| SCHEMBL6535007 | 0.79 | ALDH1A1 (0.45) | MAPTL3MBTL1CYP3A4TDP1KDM4E | |
| SCHEMBL29206234 | 0.77 | ALDH1A1 (0.41) | BAZ2BBAZ2AMAPTL3MBTL1CYP2C19 | |
| SCHEMBL6248007 | 0.76 | L3MBTL1 (0.40) | BAZ2BBAZ2AMAPTL3MBTL1CYP2C19 | |
| SCHEMBL4617203 | 0.76 | IRAK4 (0.39) | MAPTL3MBTL1TSHRCYP2C19HSD17B10 | |
| SCHEMBL25515640 | 0.76 | MAPT (0.48) | MAPTL3MBTL1TSHRHSD17B10POLB | |
| SCHEMBL25515348 | 0.76 | PTPN1 (0.42) | BAZ2BBAZ2AMAPTL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12286429-B2 | 5-oxo-1,2,3,5,8,8a-hexahydroindolizine-3-carboxamide derivatives useful as a factor XIa inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2025-04-29 | — | — | US | disclosed |
| CN-117083282-A | Tetracyclic heterocyclic compounds useful as HIV integrase inhibitors | 默沙东有限责任公司 | 2023-11-17 | — | — | CN | disclosed |
| US-20230064443-A1 | 5-oxo-1,2,3,5,8,8a-hexahydroindolizine-3-carboxamide Derivatives Useful As a Factor XIa Inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2023-03-02 | — | — | US | disclosed |
| WO-2021115457-A9 | PYRAZOLO[1,5-A]PYRIDINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 深圳众格生物科技有限公司 | 2022-05-19 | — | — | WO | disclosed |
| CN-112979645-B | Preparation method of indolizine 3-position formamide derivative | 广东药科大学 | 2022-04-19 | — | — | CN | disclosed |
| WO-2022063050-A1 | PYRAZOLE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2022-03-31 | — | — | WO | disclosed |
| CN-112979645-A | Preparation method of indolizine 3-position formamide derivative | 广东药科大学 | 2021-06-18 | — | — | CN | disclosed |
| CN-105658641-B | Benzazole amide derivatives, its preparation method and its application in medicine | 江苏恒瑞医药股份有限公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-105658641-A | Indole-amide derivative, preparation method therefor and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2016-06-08 | — | — | CN | disclosed |
| CN-102548993-B | Cyclic (aza)indolizinecarboxamides, their preparation and their use as pharmaceuticals | SANOFI AVENTIS | 2014-12-10 | — | — | CN | disclosed |
| EP-2459557-B1 | CYCLIC (AZA)INDOLIZINECARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANOFI SA (FR) | 2013-09-18 | — | — | EP | disclosed |
| US-8415336-B2 | Cyclic (aza)indolizinecarboxamides, their preparation and their use as pharmaceuticals | SANOFI (FR) | 2013-04-09 | — | — | US | disclosed |
| CN-102295644-B | Method for synthesizing 1-halo-2-aryl indolizine compound | UNIV TONGJI | 2012-12-05 | — | — | CN | disclosed |
| US-20120232081-A1 | CYCLIC (AZA)INDOLIZINECARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2012-09-13 | — | — | US | disclosed |
| CN-102548993-A | Cyclic (aza)indolizinecarboxamides, their preparation and their use as pharmaceuticals | SANOFI AVENTIS | 2012-07-04 | — | — | CN | disclosed |
| EP-2459557-A1 | CYCLIC (AZA)INDOLIZINECARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANOFI (FR) | 2012-06-06 | — | — | EP | disclosed |
| CN-102295644-A | Method for synthesizing 1-halo-2-aryl indolizine compound | — | 2011-12-28 | — | — | CN | disclosed |
| WO-1996021662-A1 | THE USE OF HETEROCYCLIC COMPOUNDS AS ANTIOXIDANTS, RADICAL SCAVENGERS, Fe2+ COMPLEXING AGENTS, TISSUE- AND/OR NEUROPROTECTANTS | RISE FRODE (NO) | 1996-07-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12286429-B2 | 5-oxo-1,2,3,5,8,8a-hexahydroindolizine-3-carboxamide derivatives useful as a factor XIa inhibitors | F11, F12, F13A1 | BAZ2B 1734/4885BAZ2A 1248/4885MAPT 4701/4885 |
| US-20230064443-A1 | 5-oxo-1,2,3,5,8,8a-hexahydroindolizine-3-carboxamide Derivatives Useful As a Factor XIa Inhibitors | F11, F12, F13A1 | BAZ2B 1631/4885BAZ2A 1156/4885MAPT 4640/4885 |
| US-20120232081-A1 | CYCLIC (AZA)INDOLIZINECARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | REN, ACE, PM20D2 | BAZ2B 523/4885BAZ2A 340/4885MAPT 4407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.