Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | IKBKB | O14920 | 2/20 | 0.58 |
| ▸ | CHUK | O15111 | 2/20 | 0.58 |
| ▸ | IKBKG | Q9Y6K9 | 2/20 | 0.58 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | NQO2 | P16083 | 1/20 | 0.55 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9473791 | 0.92 | GAA (0.84) | GAATDP1MAPTIKBKBCHUK | |
| SCHEMBL9473794 | 0.92 | GAA (0.84) | GAATDP1MAPTIKBKBCHUK | |
| SCHEMBL9472865 | 0.90 | GAA (0.82) | GAATDP1MAPTIKBKBCHUK | |
| SCHEMBL9472861 | 0.90 | GAA (0.82) | GAATDP1MAPTIKBKBCHUK | |
| SCHEMBL28552784 | 0.86 | MAPT (0.77) | GAATDP1MAPTIKBKBCHUK | |
| SCHEMBL7523992 | 0.86 | MAPT (1.00) | GAATDP1MAPTIKBKBCHUK | |
| SCHEMBL7813366 | 0.86 | GAA (0.75) | GAATDP1MAPTIKBKBCHUK | |
| SCHEMBL7813363 | 0.86 | GAA (0.75) | GAATDP1MAPTIKBKBCHUK | |
| SCHEMBL2225902 | 0.86 | GAA (0.75) | GAATDP1MAPTIKBKBCHUK | |
| SCHEMBL10375547 | 0.85 | GAA (0.73) | GAATDP1MAPTIKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2649033-B1 | COMPOSITIONS AND METHODS FOR STABILIZING INGREDIENTS USING 2,4-PENTANEDIONE COMPOUNDS | SYTHEON LTD (US) | 2018-10-17 | — | — | EP | disclosed |
| US-9908893-B2 | Thieno [2,3-b] pyridines as multidrug resistance modulators | LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2018-03-06 | — | — | US | disclosed |
| US-20160137664-A1 | THIENO [2,3-b] PYRIDINES AS MULTIDRUG RESISTANCE MODULATORS | LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2016-05-19 | — | — | US | disclosed |
| EP-3008073-A1 | THIENO[2,3-b]PYRIDINES AS MULTIDRUG RESISTANCE MODULATORS | LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2016-04-20 | — | — | EP | disclosed |
| US-20150182431-A1 | Compositions and Methods for Treatment of Hair with Reduced Hair Damage | SYTHEON LTD (US) | 2015-07-02 | — | — | US | disclosed |
| WO-2014199195-A1 | THIENO[2,3-b]PYRIDINES AS MULTIDRUG RESISTANCE MODULATORS | LATVIAN INSTITUTE OF ORGANIC SYNTHESIS (LV) | 2014-12-18 | — | — | WO | disclosed |
| US-8617528-B2 | Compositions and methods for stabilizing ingredients using 2,4-pentanedione compounds | SYTHEON LTD. (US) | 2013-12-31 | — | — | US | disclosed |
| EP-2649033-A2 | COMPOSITIONS AND METHODS FOR STABILIZING INGREDIENTS USING 2,4-PENTANEDIONE COMPOUNDS | Sytheon Ltd. (US) | 2013-10-16 | — | — | EP | disclosed |
| WO-2012078546-A2 | COMPOSITIONS AND METHODS FOR STABILIZING INGREDIENTS USING 2,4-PENTANEDIONE COMPOUNDS | SYTHEON LTD. (US) | 2012-06-14 | — | — | WO | disclosed |
| US-20120141395-A1 | COMPOSITIONS AND METHODS FOR STABILIZING INGREDIENTS USING 2,4-PENTANEDIONE COMPOUNDS | SYTHEON LIMITED (US) | 2012-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160137664-A1 | THIENO [2,3-b] PYRIDINES AS MULTIDRUG RESISTANCE MODULATORS | ABCC1, ABCB1, MT-CO1 | GAA 4793/4885TDP1 3563/4885MAPT 4273/4885 |
| US-20120141395-A1 | COMPOSITIONS AND METHODS FOR STABILIZING INGREDIENTS USING 2,4-PENTANEDIONE COMPOUNDS | HPD, GPX4, RBP4 | GAA 3228/4885TDP1 3450/4885MAPT 385/4885 |
| US-20150182431-A1 | Compositions and Methods for Treatment of Hair with Reduced Hair Damage | GPX4, COX5A, COX5B | GAA 4505/4885TDP1 2383/4885MAPT 1958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.