Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRZ1 | P23471 | 4/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.52 |
| ▸ | KIF11 | P52732 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL963353 | 0.83 | PTPRZ1 (0.63) | PTPRZ1CA2PTPN1KIF11ALDH1A1 | |
| SCHEMBL13169964 | 0.81 | PTPRZ1 (0.61) | PTPRZ1PTPN1KIF11ALDH1A1KDM4E | |
| SCHEMBL933965 | 0.81 | PTPRZ1 (0.49) | PTPRZ1PTPN1KIF11ALDH1A1KDM4E | |
| Ethane SCHEMBL11401460 | 0.80 | PTPRZ1 (0.59) | PTPRZ1CA2PTPN1ALDH1A1KDM4E | |
| SCHEMBL12986139 | 0.80 | LMNA (0.42) | PTPRZ1CA2KIF11ALDH1A1KDM4E | |
| SCHEMBL10655795 | 0.79 | PTPRZ1 (0.58) | PTPRZ1PTPN1KIF11ALDH1A1KDM4E | |
| SCHEMBL13946807 | 0.77 | PTPRZ1 (0.60) | PTPRZ1PTPN1KIF11ALDH1A1KDM4E | |
| SCHEMBL11290860 | 0.77 | CA2 (0.80) | CA2ALDH1A1KDM4E | |
| SCHEMBL30311965 | 0.76 | CA2 (0.46) | PTPRZ1CA2KIF11ALDH1A1KDM4E | |
| SCHEMBL933962 | 0.75 | PTPRZ1 (0.47) | PTPRZ1PTPN1KIF11ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140364415-A1 | PYRROLO[2,3-d]PYRIMIDINE TROPOMYSIN-RELATED KINASE INHIBITORS | PFIZER LIMITED (GB) | 2014-12-11 | — | — | US | disclosed |
| US-8846698-B2 | Pyrrolo[2,3-d]pyrimidine tropomysin-related kinase inhibitors | PFIZER LIMITED (US) | 2014-09-30 | — | — | US | disclosed |
| US-20120258950-A1 | PYRROLO[2,3-d]PYRIMIDINE TROPOMYSIN-RELATED KINASE INHIBITORS | PFIZER LIMITED (GB) | 2012-10-11 | — | — | US | disclosed |
| EP-2459569-A1 | INSECTICIDAL 4-AMINO-THIENO[2,3-D]-PYRIMIDINE COMPOUNDS AND METHODS OF THEIR USE | Merial Limited (US) | 2012-06-06 | — | — | EP | disclosed |
| US-4822903-A | Fluorinated silica catalyst and preparation of aromatic/aliphatic nitriles in the presence thereof | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1989-04-18 | — | — | US | disclosed |
| US-4504595-A | Fluorinated silica catalyst and preparation of aromatic/aliphatic nitriles in the presence thereof | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1985-03-12 | — | — | US | disclosed |
| US-4438042-A | FROM AMIDES, FLUORINATE SILCEOUS CATALYSTS | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1984-03-20 | — | — | US | disclosed |
| US-4436669-A | CYANATION, DECARBONYLATION, ACID CATALYSTS | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1984-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364415-A1 | PYRROLO[2,3-d]PYRIMIDINE TROPOMYSIN-RELATED KINASE INHIBITORS | DMPK, DTYMK, MUSK | PTPRZ1 1024/4885CA2 3769/4885PTPN1 807/4885 |
| US-20120258950-A1 | PYRROLO[2,3-d]PYRIMIDINE TROPOMYSIN-RELATED KINASE INHIBITORS | DMPK, DTYMK, MUSK | PTPRZ1 1024/4885CA2 3769/4885PTPN1 807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.