Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 6/20 | 0.38 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MPO | P05164 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | GOT1 | P17174 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.38 |
| ▸ | ACOX1 | Q15067 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9114296 | 1.00 | NPC1 (0.38) | NPC1RAB9ATP53SMN1; SMN2LMNA | |
| SCHEMBL30827215 | 0.74 | NPC1 (0.44) | NPC1RAB9ATP53SMN1; SMN2LMNA | |
| SCHEMBL224748 | 0.73 | NPC1 (0.47) | NPC1RAB9ATP53SMN1; SMN2LMNA | |
| SCHEMBL5436460 | 0.73 | NPC1 (0.47) | NPC1RAB9ATP53SMN1; SMN2LMNA | |
| SCHEMBL7547757 | 0.70 | NPC1 (0.44) | NPC1RAB9ATP53SMN1; SMN2LMNA | |
| SCHEMBL8152019 | 0.70 | NPC1 (0.44) | NPC1RAB9ATP53SMN1; SMN2LMNA | |
| SCHEMBL291352 | 0.70 | NPC1 (0.47) | NPC1RAB9ATP53SMN1; SMN2LMNA | |
| SCHEMBL6008542 | 0.70 | NPC1 (0.47) | NPC1RAB9ATP53SMN1; SMN2LMNA | |
| SCHEMBL6003040 | 0.69 | RXRA (0.45) | PTGS1 | |
| SCHEMBL29982208 | 0.69 | S100A4 (0.41) | NPC1RAB9ATP53SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0670831-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-09-13 | — | — | EP | disclosed |
| WO-1995009159-A1 | QUINOXALINE DERIVATIVE AS ANTIDIABETIC AGENT | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1995-04-06 | — | — | WO | disclosed |