Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 11/20 | 0.50 |
| ▸ | SGMS2 | Q8NHU3 | 4/20 | 0.49 |
| ▸ | PPIF | P30405 | 2/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9127445 | 0.90 | PPIA (0.48) | PPIASGMS2PPIFRAB9ANPC1 | |
| SCHEMBL9124958 | 0.89 | PPIA (0.56) | PPIASGMS2PPIFRAB9ASGMS1 | |
| SCHEMBL9123466 | 0.88 | PPIA (0.50) | PPIASGMS2PPIFRAB9AMAPT | |
| SCHEMBL9127894 | 0.86 | PPIA (0.55) | PPIASGMS2PPIFRAB9ASGMS1 | |
| SCHEMBL9127827 | 0.85 | PPIA (0.50) | PPIASGMS2PPIFRAB9AALDH1A1 | |
| SCHEMBL9124032 | 0.84 | PPIA (0.53) | PPIASGMS2PPIFRAB9AMAPT | |
| SCHEMBL9124706 | 0.83 | PPIA (0.50) | PPIASGMS2PPIF | |
| SCHEMBL9126123 | 0.83 | PPIA (0.54) | PPIASGMS2RAB9ASGMS1NPC1 | |
| SCHEMBL9128706 | 0.83 | PPIA (0.52) | PPIASGMS2PPIFRAB9AMAPT | |
| SCHEMBL9125073 | 0.80 | PPIA (0.75) | PPIAPPIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5409943-A | [(alkoxy)pyridinyl]amine compounds which are useful in the treatment of gastrointestinal disorders | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1995-04-25 | — | — | US | disclosed |
| EP-0625143-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015055-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-08-05 | — | — | WO | disclosed |