Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIA | P62937 | 4/20 | 0.44 |
| ▸ | PPIF | P30405 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 5/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9126099 | 0.90 | PPIF (0.41) | PPIAPPIFSIGMAR1 | |
| SCHEMBL9124036 | 0.85 | PPIF (0.48) | PPIAPPIFSIGMAR1 | |
| SCHEMBL9127446 | 0.84 | SGMS2 (0.46) | PPIAPPIFSIGMAR1 | |
| SCHEMBL9125354 | 0.84 | SGMS2 (0.46) | PPIAPPIFSIGMAR1 | |
| SCHEMBL9128712 | 0.84 | PPIA (0.43) | PPIAPPIFSIGMAR1 | |
| SCHEMBL9124960 | 0.83 | PPIA (0.47) | PPIAPPIFSIGMAR1 | |
| SCHEMBL9125719 | 0.82 | PPIA (0.40) | PPIAPPIFSIGMAR1 | |
| SCHEMBL9127905 | 0.82 | PPIA (0.45) | PPIAPPIFSIGMAR1 | |
| SCHEMBL9126127 | 0.82 | PPIA (0.45) | PPIAPPIFSIGMAR1 | |
| SCHEMBL9125077 | 0.81 | PPIA (0.62) | PPIAPPIFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5409943-A | [(alkoxy)pyridinyl]amine compounds which are useful in the treatment of gastrointestinal disorders | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1995-04-25 | — | — | US | disclosed |
| EP-0625143-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1994-11-23 | — | — | EP | disclosed |
| WO-1993015055-A1 | PYRIDINE DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINES | SMITHKLINE BEECHAM INTERCREDIT B.V. (NL) | 1993-08-05 | — | — | WO | disclosed |