Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 2/20 | 0.50 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.50 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | F2R | P25116 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10964731 | 0.72 | CASP3 (0.47) | MAPK13MAPK12MAPK11MAPK14MAPT | |
| SCHEMBL9130561 | 0.70 | L3MBTL1 (0.42) | NPC1RAB9AMAPTGAASMN1; SMN2 | |
| SCHEMBL11409753 | 0.69 | ALDH1A1 (0.38) | NPC1RAB9AMAPTGAASMN1; SMN2 | |
| SCHEMBL8022715 | 0.69 | MAPT (0.50) | NPC1RAB9AMAPTGAASMN1; SMN2 | |
| SCHEMBL1681866 | 0.68 | PRNP (0.53) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL29470997 | 0.68 | PRNP (0.53) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL9679485 | 0.66 | PRNP (0.57) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL3844423 | 0.66 | PRNP (0.57) | MAPK13MAPK12MAPK11MAPK14NPC1 | |
| SCHEMBL10803715 | 0.66 | MAPT (0.50) | NPC1RAB9AMAPTGAASMN1; SMN2 | |
| SCHEMBL723657 | 0.65 | AKR1C3 (0.61) | MAPK13MAPK12MAPK11MAPK14NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5439916-A | Antiallergens,-inflammatory and -ulcer agents; hypotensive agents; immunosuppressants; skin disorders | SCHERING CORPORATION (US) | 1995-08-08 | — | — | US | disclosed |
| US-5126352-A | Antiallergy, antiinflammatory, antiulcer, hypotensive, antibody inhibitors | SCHERING CORPORATION (US) | 1992-06-30 | — | — | US | disclosed |
| US-5116840-A | Antiulcer, antiinflammatory, hypotensive, immunosuppressants | SCHERING CORPORATION (US) | 1992-05-26 | — | — | US | disclosed |
| EP-0229823-B1 | POLYCYCLIC QUINOLINE, NAPHTHYRIDINE AND PYRAZINOPYRIDINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-09-25 | — | — | EP | disclosed |
| US-4988705-A | Antiallergens and -inflammatory agents; hypotensive agents immunological suppression; hyperproliferative skin disorders such as psoriasis | SCHERING CORPORATION (US) | 1991-01-29 | — | — | US | disclosed |
| US-4810708-A | ANTIALLERGY, IMMUNOSUPPRESSIVE | SCHERING CORPORATION (US) | 1989-03-07 | — | — | US | disclosed |