SCHEMBL9135451

SCHEMBL9135451

Cc1cc(NC(=O)NC(=O)c2c(F)cccc2Cl)c(C)c(Cl)c1Oc1ncc(C#N)cc1Cl

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
KDM4E B2RXH2 1/20 0.40
NPC1 O15118 1/20 0.40
ALDH1A1 P00352 1/20 0.40
MAPK1 P28482 1/20 0.40
SCN9A Q15858 4/20 0.38
MET P08581 1/20 0.37
RORC P51449 3/20 0.37
GAA P10253 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
MAPT P10636 2/20 0.36
USP2 O75604 1/20 0.36
ALOX15 P16050 1/20 0.36
GPR6 P46095 1/20 0.35
TLR8 Q9NR97 1/20 0.35
P2RX7 Q99572 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8662513 0.97 MEN1 (0.45) MEN1KMT2AKDM4ENPC1ALDH1A1
SCHEMBL8655814 0.94 TAS1R3 (0.38) MEN1KMT2AKDM4ENPC1ALDH1A1
SCHEMBL8658809 0.89 KDM4E (0.43) MEN1KMT2AKDM4ENPC1ALDH1A1
SCHEMBL8656206 0.88 KDM4E (0.46) MEN1KMT2AKDM4ENPC1ALDH1A1
SCHEMBL8658220 0.87 PYGL (0.43) NPC1SCN9A
SCHEMBL8660997 0.86 MEN1 (0.48) MEN1KMT2AKDM4ENPC1ALDH1A1
SCHEMBL8659922 0.85 MET (0.42) MEN1KMT2AKDM4ENPC1ALDH1A1
SCHEMBL8663086 0.84 MEN1 (0.43) MEN1KMT2AKDM4ENPC1ALDH1A1
SCHEMBL10641209 0.84 KDM4E (0.46) MEN1KMT2AKDM4ENPC1ALDH1A1
SCHEMBL8659341 0.83 KDM4E (0.47) MEN1KMT2AKDM4ENPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5420163-A Insecticides or miticides CIBA-GEIGY (US) 1995-05-30 US disclosed
US-5135953-A Oral or injections; cattle, swine, poultry CIBA-GEIGY (US) 1992-08-04 US disclosed
EP-0115210-B1 PESTICIDAL BENZOYL UREAS AND PROCESS FOR THEIR PREPARATION UNION CARBIDE CORPORATION (US) 1988-05-11 EP disclosed
US-4659724-A Certain 1-[4-(5-cyano-2-pyridyloxy)phenyl-benzoyl ureas having pesticidal properties UNION CARBIDE CORPORATION (US) 1987-04-21 US disclosed
EP-0211004-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS RHONE-POULENC NEDERLAND B.V. (NL) 1987-02-25 EP disclosed
WO-1986003941-A1 USE OF ACYL UREA COMPOUNDS FOR CONTROLLING ENDOPARASITES AND ECTOPARASITES OF WARM-BLOODED ANIMALS UNION CARBIDE CORPORATION (US) 1986-07-17 WO disclosed
EP-0115210-A1 Pesticidal benzoyl ureas and process for their preparation UNION CARBIDE CORPORATION (US) 1984-08-08 EP disclosed