Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 4/20 | 0.68 |
| ▸ | MARS1 | P56192 | 1/20 | 0.63 |
| ▸ | RPA1 | P27694 | 3/20 | 0.60 |
| ▸ | RXRA | P19793 | 1/20 | 0.60 |
| ▸ | RXRB | P28702 | 1/20 | 0.60 |
| ▸ | RXRG | P48443 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.59 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | CCKAR | P32238 | 5/20 | 0.58 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.58 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9749563 | 0.89 | PTGS2 (0.73) | MALT1MARS1RPA1PTGS2ALOX5 | |
| SCHEMBL5393447 | 0.83 | RXRA (0.84) | MALT1RXRARXRBRXRGPTGS2 | |
| SCHEMBL9353410 | 0.81 | CHRNA7 (0.72) | MALT1MARS1RPA1PTGS2ALOX5 | |
| SCHEMBL9056282 | 0.80 | RPA1 (0.90) | MALT1MARS1RPA1SMN1; SMN2CHRNA7 | |
| SCHEMBL9149353 | 0.79 | PTGS2 (0.60) | MALT1RPA1PTGS2ALOX5CCKAR | |
| SCHEMBL3262361 | 0.78 | CHRNA7 (0.72) | MALT1MARS1RPA1PTGS2CCKAR | |
| SCHEMBL117493 | 0.77 | MARS1 (1.00) | MALT1MARS1RPA1SMN1; SMN2PPP1CA | |
| SCHEMBL9349843 | 0.77 | CCKAR (0.60) | MALT1MARS1RXRARXRBRXRG | |
| SCHEMBL9519465 | 0.77 | PTGS2 (0.79) | MALT1MARS1RXRARXRBRXRG | |
| SCHEMBL9349407 | 0.76 | SMN1; SMN2 (0.63) | MALT1MARS1RPA1PTGS2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5869674-A | DI-2-((1,5,4-SUBSTITUTED)-PYRAZOL-3-YL) ETHYLCARBONATE, WITH AT LEAST ONE 2-QUINOLINYLMETHOXYPHENYL GROUP ON PYRAZOL | ORTHO PHARMACEUTICAL CORPORATION (US) | 1999-02-09 | — | — | US | disclosed |
| US-5843958-A | Arylpyrazoles as leukotriene inhibitors | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-12-01 | — | — | US | disclosed |