Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 5/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTR5A | P47898 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29109614 | 0.70 | TOP1 (0.44) | ACHEGAAALDH1A1MAPTKDM4E | |
| SCHEMBL6220558 | 0.70 | TRPA1 (0.40) | TRPA1HTR2AACHEGAAALDH1A1 | |
| SCHEMBL7049728 | 0.69 | PTGS2 (0.42) | HTR2AACHEALDH1A1MAPTBCHE | |
| SCHEMBL9573511 | 0.69 | HTR2C (0.47) | ACHEBCHE | |
| Hydrochloric Acid SCHEMBL1132331 | 0.68 | HTR2C (0.46) | ACHEBCHE | |
| SCHEMBL8824467 | 0.67 | HTR5A (0.39) | ACHEALDH1A1MAPTBCHEKDM4E | |
| SCHEMBL2047592 | 0.66 | TOP1 (0.47) | HTR2AACHEGAAALDH1A1MAPT | |
| SCHEMBL1647356 | 0.66 | MAPT (0.52) | HTR2AACHEGAAALDH1A1MAPT | |
| SCHEMBL4306589 | 0.66 | ACHE (0.38) | HTR2AACHEALDH1A1MAPTBCHE | |
| SCHEMBL642263 | 0.65 | TRPA1 (0.59) | TRPA1BCHECYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061763-B1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATES | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-16 | — | — | EP | disclosed |
| US-7872138-B2 | Process for the preparation of substituted-1,2,3,4-tetrahydroisoquinoline derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2011-01-18 | — | — | US | disclosed |
| EP-2061763-A2 | PROCESS FOR THE PREPARATION OF SUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATES | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008019356-A2 | PROCESS FOR THE PREPARATION OF SUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-02-14 | — | — | WO | disclosed |
| US-20080033177-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080033177-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED-1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES | CYP3A4, CYP4B1, CYP3A5 | TRPA1 4405/4885HTR2A 290/4885ACHE 2688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.