Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.30 |
| ▸ | TUBB | P07437 | 2/20 | 0.30 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.30 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.30 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.30 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.30 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.30 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9160957 | 0.91 | SMN1; SMN2 (0.33) | SMN1; SMN2PTGS2MEN1KMT2ATUBB4A | |
| SCHEMBL9159345 | 0.86 | PTGS2 (0.38) | SMN1; SMN2PTGS2MEN1KMT2ATUBB4A | |
| SCHEMBL9164191 | 0.84 | TUBB1 (0.37) | SMN1; SMN2PTGS2MEN1KMT2ATUBB4A | |
| SCHEMBL9687366 | 0.73 | PDE2A (0.41) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9687454 | 0.65 | MEN1 (0.39) | MEN1KMT2AMAPT | |
| SCHEMBL9025791 | 0.63 | KMT2A (0.36) | POLBSMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL5572443 | 0.63 | PTGS2 (0.59) | PTGS2HTR2AHTR2CHTR2BMAPT | |
| SCHEMBL8910416 | 0.60 | PTGS2 (0.70) | DHFRPTGS2MEN1KMT2AHTR2A | |
| SCHEMBL10998613 | 0.57 | PTGS2 (0.59) | PTGS2HTR2AHTR2CHTR2BGAA | |
| SCHEMBL7714729 | 0.57 | DHFR (0.58) | DHFRSMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |