Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HMGCR | P04035 | 3/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PTGES | O14684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9689006 | 0.77 | ALDH1A1 (0.38) | ALDH1A1GAATDP1HMGCRSERPINE1 | |
| SCHEMBL9686898 | 0.64 | HMGCR (0.35) | ALDH1A1GAATDP1HMGCRMAPT | |
| SCHEMBL8944759 | 0.60 | ALDH1A1 (0.64) | ALDH1A1GAATDP1HMGCRPTGS2 | |
| SCHEMBL8944534 | 0.60 | L3MBTL1 (0.60) | ALDH1A1GAATDP1PTGS1MAPT | |
| SCHEMBL295404 | 0.59 | ALDH1A1 (0.72) | ALDH1A1GAATDP1PTGS1PTGS2 | |
| SCHEMBL2276660 | 0.59 | GAA (1.00) | ALDH1A1GAATDP1PTGS1PTGS2 | |
| SCHEMBL29282569 | 0.59 | ALDH1A1 (0.62) | ALDH1A1GAATDP1MAPTCA1 | |
| SCHEMBL10600586 | 0.59 | GAA (0.62) | ALDH1A1GAATDP1MAPTVCAM1 | |
| SCHEMBL10602494 | 0.59 | ALDH1A1 (0.62) | ALDH1A1GAATDP1MAPTVCAM1 | |
| SCHEMBL3483031 | 0.59 | GAA (0.66) | ALDH1A1GAATDP1MAPTCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459142-A | Autoimmune disease, atherosclerosis, antiischemic agents and nephritis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-17 | — | — | US | disclosed |