Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | GSR | P00390 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687454 | 0.88 | MEN1 (0.39) | KMT2AMEN1TDP1MAPTKDM4E | |
| SCHEMBL9689006 | 0.87 | ALDH1A1 (0.38) | HMGCRGAATDP1KDM4EALDH1A1 | |
| SCHEMBL9687392 | 0.81 | CYP1A2 (0.46) | KMT2AMEN1GAAMAPTKDM4E | |
| SCHEMBL9687911 | 0.81 | HMGCR (0.37) | HMGCRKMT2AMEN1GAAMAPT | |
| SCHEMBL9687941 | 0.77 | EZH2 (0.40) | KMT2AMEN1KDM4E | |
| SCHEMBL9687391 | 0.73 | HPGD (0.39) | KMT2AMEN1GAAMAPTALDH1A1 | |
| SCHEMBL9164716 | 0.72 | HMGCR (0.37) | HMGCRGSRKMT2AMEN1GAA | |
| SCHEMBL9164617 | 0.68 | NPC1 (0.51) | KMT2AMEN1GAAMAPTKDM4E | |
| SCHEMBL9162897 | 0.64 | ALDH1A1 (0.39) | HMGCRGAATDP1MAPTKDM4E | |
| SCHEMBL14035134 | 0.63 | GSR (0.57) | GSRKMT2AMEN1GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |