SCHEMBL8944759

SCHEMBL8944759

COC(=O)C(=O)Nc1cc(C(C)(C)C)c(O)c(C(C)(C)C)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.64
GAA P10253 3/20 0.64
TDP1 Q9NUW8 1/20 0.64
CA2 P00918 3/20 0.47
CA1 P00915 2/20 0.47
SMN1; SMN2 Q16637 2/20 0.42
POLB P06746 1/20 0.42
TYR P14679 1/20 0.42
GLRA3 O75311 1/20 0.42
GLRB P48167 1/20 0.42
VCAM1 P19320 1/20 0.40
HMGCR P04035 1/20 0.40
GPR35 Q9HC97 1/20 0.40
MEN1 O00255 1/20 0.40
GALR3 O60755 1/20 0.40
HTT P42858 1/20 0.40
KMT2A Q03164 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
LMNA P02545 1/20 0.39
RECQL P46063 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9275814 0.90 ALDH1A1 (0.56) ALDH1A1GAATDP1HMGCRGPR35
SCHEMBL8944855 0.84 ALDH1A1 (0.57) ALDH1A1GAATDP1HMGCRGPR35
SCHEMBL9812317 0.82 GAA (0.68) ALDH1A1GAATDP1CA2CA1
SCHEMBL8335780 0.79 GAA (0.64) ALDH1A1GAATDP1CA2CA1
SCHEMBL9807633 0.79 GAA (0.69) ALDH1A1GAATDP1CA2CA1
SCHEMBL9313906 0.78 LMNA (0.48) ALDH1A1GAATDP1CA2CA1
SCHEMBL295404 0.78 ALDH1A1 (0.72) ALDH1A1GAATDP1CA2CA1
SCHEMBL2276660 0.78 GAA (1.00) ALDH1A1GAATDP1CA2CA1
SCHEMBL9160065 0.77 GAA (0.70) ALDH1A1GAATDP1CA2CA1
SCHEMBL8944534 0.76 L3MBTL1 (0.60) ALDH1A1GAATDP1SMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5578731-A ASYMMETRICAL HYDRAZINE DERIVATIVE CIBA-GEIGY CORPORATION (US) 1996-11-26 US disclosed
US-5554754-A PHOTOSTABILIZERS CIBA-GEIGY CORPORATION (US) 1996-09-10 US disclosed
US-5470980-A Light stabilizers for polymers that can be grafted to polymers CIBA-GEIGY CORPORATION (US) 1995-11-28 US disclosed
US-5397821-A Light and heat stabilizers, low volatility ELFATOCHEM NORTH AMERICA, INC. (US) 1995-03-14 US disclosed
US-5352719-A Blended with synthetic or natural polymers ELF ATOCHEM NORTH AMERICA, INC. (US) 1994-10-04 US disclosed
US-5338853-A N-(2,2,6,6-tetraalkyl-4-piperidinyl)amic acid hydrazides; contain light stabilizing group and heat stabilizing group ELF ATOCHEM NORTH AMERICA, INC. (US) 1994-08-16 US disclosed
US-5319090-A Benzotriazole and oxanilide UV absorber hydrazides ELF ATOCHEM NORTH AMERICA, INC. (US) 1994-06-07 US disclosed
US-5233047-A Benzotriazole UV absorber hydrazides ELF ATOCHEM NORTH AMERICA, INC. (US) 1993-08-03 US disclosed
US-5116976-A HINDERED AMINE LIGHT STABILIZER HYDRAZIDES ATOCHEM NORTH AMERICA, INC (US) 1992-05-26 US disclosed
EP-0467344-A1 Hindered amine light stabilizer hydrazides ELF ATOCHEM NORTH AMERICA, INC. (US) 1992-01-22 EP disclosed
US-5041545-A 2-hydroxybenzophenone hydrazides and derivatives thereof ATOCHEM NORTH AMERICA, INC. (US) 1991-08-20 US disclosed
US-4980420-A Benzotriazole and oxanilide UV absorber hydrazides ATOCHEM NORTH AMERICA, INC. (US) 1990-12-25 US disclosed