Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | JUN | P05412 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | GUSB | P08236 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9164566 | 1.00 | NFKB1 (0.47) | NFKB1CDK4CCND1JUNNFE2L2 | |
| SCHEMBL9164572 | 0.78 | CDK4 (0.55) | NFKB1CDK4CCND1JUNNFE2L2 | |
| SCHEMBL3415700 | 0.76 | CA2 (0.50) | NFKB1CDK4CCND1JUNNFE2L2 | |
| SCHEMBL347703 | 0.76 | TRPA1 (0.48) | NFKB1CDK4CCND1JUNNFE2L2 | |
| SCHEMBL3415698 | 0.76 | CA2 (0.50) | NFKB1CDK4CCND1JUNNFE2L2 | |
| SCHEMBL30337793 | 0.76 | CA2 (0.50) | NFKB1CDK4CCND1JUNNFE2L2 | |
| SCHEMBL9574440 | 0.75 | NFKB1 (0.55) | NFKB1CDK4CCND1JUNNFE2L2 | |
| SCHEMBL4453048 | 0.74 | TRPA1 (0.47) | NFKB1CDK4CCND1JUNNFE2L2 | |
| SCHEMBL11189518 | 0.73 | CDK4 (0.59) | NFKB1CDK4CCND1JUNNFE2L2 | |
| SCHEMBL97313 | 0.73 | PAM (0.48) | LMNATRPA1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459142-A | Autoimmune disease, atherosclerosis, antiischemic agents and nephritis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0511879-B1 | Pyrazine derivatives | OTSUKA PHARMA CO LTD (JP) | 1995-03-22 | — | — | EP | disclosed |
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |