Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687911 | 0.87 | HMGCR (0.37) | HMGCRALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL9686898 | 0.72 | HMGCR (0.35) | HMGCRALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL9689006 | 0.69 | ALDH1A1 (0.38) | HMGCRALDH1A1GAATDP1KDM4E | |
| SCHEMBL39082 | 0.68 | HMGCR (0.57) | HMGCRALDH1A1TSHRMEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL11660895 | 0.66 | HMGCR (0.55) | HMGCRALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL17433310 | 0.66 | HSPA5 (0.51) | HMGCRALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL9160957 | 0.66 | SMN1; SMN2 (0.33) | TSHRMEN1KMT2ACYP2C9ALOX15 | |
| SCHEMBL15142812 | 0.64 | HSPA5 (0.57) | HMGCRALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL39559 | 0.64 | ALDH1A1 (0.63) | ALDH1A1TSHRMEN1KMT2AMAPK1 | |
| SCHEMBL10788571 | 0.63 | CA2 (0.43) | HMGCRALDH1A1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459142-A | Autoimmune disease, atherosclerosis, antiischemic agents and nephritis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0511879-B1 | Pyrazine derivatives | OTSUKA PHARMA CO LTD (JP) | 1995-03-22 | — | — | EP | disclosed |
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |