Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9164716 | 0.87 | HMGCR (0.37) | HMGCRALDH1A1TSHRGAALMNA | |
| SCHEMBL9686898 | 0.81 | HMGCR (0.35) | HMGCRALDH1A1GAAMEN1KMT2A | |
| SCHEMBL9160957 | 0.81 | SMN1; SMN2 (0.33) | TSHRCA1CA2MEN1KMT2A | |
| SCHEMBL9687418 | 0.73 | POLB (0.34) | GAAMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL9026919 | 0.68 | AKR1C2 (0.45) | ALDH1A1TSHRGAAMAPTKDM4E | |
| SCHEMBL9025829 | 0.68 | MAPT (0.42) | ALDH1A1TSHRGAAMEN1KMT2A | |
| SCHEMBL9026831 | 0.67 | IDO1 (0.45) | MEN1KMT2A | |
| SCHEMBL9026293 | 0.67 | TUBB4A (0.43) | — | |
| SCHEMBL9687454 | 0.67 | MEN1 (0.39) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL9027098 | 0.66 | SOS2 (0.43) | MAPTNPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |