Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450504 | 0.74 | FDPS (0.41) | FDPSHDAC1HDAC6ALDH1A1TSHR | |
| SCHEMBL7592031 | 0.74 | FDPS (0.40) | FDPSDNMT3BHDAC1HDAC6ALDH1A1 | |
| SCHEMBL11543167 | 0.73 | FDPS (0.42) | FDPSDNMT3BHDAC1HDAC6ALDH1A1 | |
| SCHEMBL9081767 | 0.73 | HDAC1 (0.40) | FDPSDNMT3BHDAC1HDAC6ALDH1A1 | |
| SCHEMBL9177163 | 0.72 | FDPS (0.38) | FDPSDNMT3BHDAC1HDAC6ALDH1A1 | |
| SCHEMBL14125938 | 0.72 | FDPS (0.43) | FDPSHDAC1HDAC6ALDH1A1TSHR | |
| SCHEMBL7452633 | 0.71 | FDPS (0.40) | FDPSHDAC1HDAC6ALDH1A1TSHR | |
| SCHEMBL7595395 | 0.69 | FDPS (0.39) | FDPSHDAC1HDAC6ALDH1A1TSHR | |
| SCHEMBL27535766 | 0.69 | FDPS (0.40) | FDPSDNMT3BHDAC1HDAC6ALDH1A1 | |
| SCHEMBL7457885 | 0.69 | FDPS (0.37) | FDPSDNMT3BHDAC1HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426467-B1 | Prodrugs of 6-mercaptopurine and 6-thioguanine | WISCONSIN ALUMNI RES FOUND (US) | 1995-04-05 | — | — | EP | disclosed |
| US-5120740-A | PRODRUGS OF 6-MERCAPTOPURINE AND 6-THIOGUANINE | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0426467-A1 | Prodrugs of 6-mercaptopurine and 6-thioguanine | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1991-05-08 | — | — | EP | disclosed |