Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9168133 | 0.78 | PTPN1 (0.46) | ALDH1A1L3MBTL1 | |
| SCHEMBL9168167 | 0.78 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL9173922 | 0.75 | PTPN1 (0.43) | ALDH1A1L3MBTL1 | |
| SCHEMBL2950164 | 0.72 | RXRA (0.43) | NPC1RAB9A | |
| SCHEMBL29388499 | 0.72 | TTR (0.59) | L3MBTL1TTRNPC1RAB9AMAP2K4 | |
| SCHEMBL6350818 | 0.72 | TTR (0.59) | L3MBTL1TTRNPC1RAB9AMAP2K4 | |
| Dibenzothiophene SCHEMBL8068874 | 0.70 | TSHR (0.61) | ALDH1A1L3MBTL1MCL1RAB9ANPSR1 | |
| SCHEMBL12389958 | 0.70 | L3MBTL1 (0.46) | ALDH1A1L3MBTL1TTRGRIA4RAB9A | |
| SCHEMBL5793081 | 0.70 | CYP11B2 (0.44) | ALDH1A1NPC1RAB9A | |
| SCHEMBL9176872 | 0.69 | TNKS (0.51) | ALDH1A1TTRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |