Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 8/20 | 0.47 |
| ▸ | RXRB | P28702 | 5/20 | 0.47 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.47 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.47 |
| ▸ | RXRG | P48443 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 2/20 | 0.38 |
| ▸ | RARG | P13631 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9180083 | 0.85 | NOS1 (0.40) | RXRARXRBCYP26A1CYP26B1TSHR | |
| SCHEMBL9185034 | 0.84 | RXRA (0.43) | RXRARXRBCYP26A1CYP26B1RXRG | |
| SCHEMBL9179713 | 0.82 | ALDH1A1 (0.42) | HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL9184572 | 0.82 | HDAC1 (0.50) | ALOX15CA12CA1CA2CA9 | |
| SCHEMBL9179652 | 0.79 | PTPN1 (0.50) | HPGDALDH1A1SMN1; SMN2POLBPKM | |
| SCHEMBL18086910 | 0.77 | OPRM1 (0.37) | TSHRALDH1A1SMN1; SMN2POLB | |
| SCHEMBL22250079 | 0.76 | SRD5A2 (0.57) | RXRARXRBCYP26A1CYP26B1RXRG | |
| SCHEMBL9178844 | 0.74 | MAPK1 (0.37) | RXRATSHRALDH1A1SMN1; SMN2POLB | |
| SCHEMBL11740144 | 0.72 | NOS3 (0.36) | ALDH1A1 | |
| SCHEMBL22249947 | 0.72 | RXRA (0.56) | RXRARXRBCYP26A1CYP26B1RXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5378728-A | Benzoic acid derivatives as antidiabetic agents | SANDOZ LTD. (CH) | 1995-01-03 | — | — | US | claimed |
| US-5378728-A | Benzoic acid derivatives as antidiabetic agents | SANDOZ LTD. (CH) | 1995-01-03 | — | — | US | disclosed |